Effects and cost-effectiveness of pharmacogenetic screening for CYP2D6 among older adults starting therapy with nortriptyline or venlafaxine: study protocol for a pragmatic randomized controlled trial (CYSCEtrial)

BACKGROUND: Nortriptyline and venlafaxine are commonly used antidepressants for treatment of depression in older patients. Both drugs are metabolized by the polymorphic cytochrome P450-2D6 (CYP2D6) enzyme and guidelines for dose adaptations based on the CYP2D6 genotype have been developed. The CYP2D...

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Detalles Bibliográficos
Autores principales: Berm, Elizabeth JJ, Hak, Eelko, Postma, Maarten, Boshuisen, Marjolein, Breuning, Laura, Brouwers, Jacobus RBJ, Dhondt, Ton, Jansen, Paul AF, Kok, Rob M, Maring, Jan G, van Marum, Rob, Mulder, Hans, Voshaar, Richard C Oude, Risselada, Arne J, Venema, Harry, Vleugel, Liesbeth, Wilffert, Bob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328880/
https://www.ncbi.nlm.nih.gov/pubmed/25636328
http://dx.doi.org/10.1186/s13063-015-0561-0

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