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Restoring physiological levels of ascorbate slows tumor growth and moderates HIF-1 pathway activity in Gulo(−/−) mice

Hypoxia-inducible factor-1 (HIF-1) governs cellular adaption to the hypoxic microenvironment and is associated with a proliferative, metastatic, and treatment-resistant tumor phenotype. HIF-1 levels and transcriptional activity are regulated by proline and asparagine hydroxylases, which require asco...

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Detalles Bibliográficos
Autores principales:	Campbell, Elizabeth J, Vissers, Margreet C M, Bozonet, Stephanie, Dyer, Arron, Robinson, Bridget A, Dachs, Gabi U
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Cancer Prevention
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329013/ https://www.ncbi.nlm.nih.gov/pubmed/25354695 http://dx.doi.org/10.1002/cam4.349

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