Calcineurin inhibitors differentially alter the circadian rhythm of T-cell functionality in transplant recipients

BACKGROUND: Graft survival in transplant recipients depends on pharmacokinetics and on individual susceptibility towards immunosuppressive drugs. Nevertheless, pharmacodynamic changes in T-cell functionality in response to drugs and in relation to pharmacokinetics are poorly characterized. We theref...

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Detalles Bibliográficos
Autores principales: Leyking, Sarah, Budich, Karin, van Bentum, Kai, Thijssen, Stephan, Abdul-Khaliq, Hashim, Fliser, Danilo, Sester, Martina, Sester, Urban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329209/
https://www.ncbi.nlm.nih.gov/pubmed/25885792
http://dx.doi.org/10.1186/s12967-015-0420-5

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