Gene expression signatures in motor neurone disease fibroblasts reveal dysregulation of metabolism, hypoxia-response and RNA processing functions

AIMS: Amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS) are two syndromic variants within the motor neurone disease spectrum. As PLS and most ALS cases are sporadic (SALS), this limits the availability of cellular models for investigating pathogenic mechanisms and therapeutic t...

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Detalles Bibliográficos
Autores principales: Raman, R, Allen, S P, Goodall, E F, Kramer, S, Ponger, L-L, Heath, P R, Milo, M, Hollinger, H C, Walsh, T, Highley, J R, Olpin, S, McDermott, C J, Shaw, P J, Kirby, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329387/
https://www.ncbi.nlm.nih.gov/pubmed/24750211
http://dx.doi.org/10.1111/nan.12147

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