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Single-step generation of rabbits carrying a targeted allele of the tyrosinase gene using CRISPR/Cas9

Targeted genome editing of nonrodent mammalian species has provided the potential for highly accurate interventions into gene function in humans and the generation of useful animal models of human diseases. Here we show successful clustered regularly interspaced short palindromic repeat (CRISPR) and...

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Detalles Bibliográficos
Autores principales:	Honda, Arata, Hirose, Michiko, Sankai, Tadashi, Yasmin, Lubna, Yuzawa, Kazuaki, Honsho, Kimiko, Izu, Haruna, Iguchi, Atsushi, Ikawa, Masahito, Ogura, Atsuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Japanese Association for Laboratory Animal Science 2014
Materias:	Original
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329513/ https://www.ncbi.nlm.nih.gov/pubmed/25195632 http://dx.doi.org/10.1538/expanim.14-0034

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