Double minute amplification of mutant PDGF receptor α in a mouse glioma model

In primary brain tumors, oncogenes are frequently amplified and maintained on extrachromosomal DNA as double minutes (DM), but the underlying mechanisms remain poorly understood. We have generated a mouse model of malignant glioma based on knock-in of a mutant PDGF receptor α (PDGFRα) that is expres...

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Detalles Bibliográficos
Autores principales: Zou, Hongyan, Feng, Rui, Huang, Yong, Tripodi, Joseph, Najfeld, Vesna, Tsankova, Nadejda M., Jahanshahi, Maryam, Olson, Lorin E., Soriano, Philippe, Friedel, Roland H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329559/
https://www.ncbi.nlm.nih.gov/pubmed/25683249
http://dx.doi.org/10.1038/srep08468

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