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Friend or foe: Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer
The endoplasmic reticulum (ER) protein 29 (ERp29) is a molecular chaperone that plays a critical role in protein secretion from the ER in eukaryotic cells. Recent studies have also shown that ERp29 plays a role in cancer. It has been demonstrated that ERp29 is inversely associated with primary tumor...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329646/ https://www.ncbi.nlm.nih.gov/pubmed/25709888 http://dx.doi.org/10.1016/j.fob.2015.01.004 |
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author | Chen, Shaohua Zhang, Daohai |
author_facet | Chen, Shaohua Zhang, Daohai |
author_sort | Chen, Shaohua |
collection | PubMed |
description | The endoplasmic reticulum (ER) protein 29 (ERp29) is a molecular chaperone that plays a critical role in protein secretion from the ER in eukaryotic cells. Recent studies have also shown that ERp29 plays a role in cancer. It has been demonstrated that ERp29 is inversely associated with primary tumor development and functions as a tumor suppressor by inducing cell growth arrest in breast cancer. However, ERp29 has also been reported to promote epithelial cell morphogenesis, cell survival against genotoxic stress and distant metastasis. In this review, we summarize the current understanding on the biological and pathological functions of ERp29 in cancer and discuss the pivotal aspects of ERp29 as “friend or foe” in epithelial cancer. |
format | Online Article Text |
id | pubmed-4329646 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-43296462015-02-23 Friend or foe: Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer Chen, Shaohua Zhang, Daohai FEBS Open Bio Review The endoplasmic reticulum (ER) protein 29 (ERp29) is a molecular chaperone that plays a critical role in protein secretion from the ER in eukaryotic cells. Recent studies have also shown that ERp29 plays a role in cancer. It has been demonstrated that ERp29 is inversely associated with primary tumor development and functions as a tumor suppressor by inducing cell growth arrest in breast cancer. However, ERp29 has also been reported to promote epithelial cell morphogenesis, cell survival against genotoxic stress and distant metastasis. In this review, we summarize the current understanding on the biological and pathological functions of ERp29 in cancer and discuss the pivotal aspects of ERp29 as “friend or foe” in epithelial cancer. Elsevier 2015-01-30 /pmc/articles/PMC4329646/ /pubmed/25709888 http://dx.doi.org/10.1016/j.fob.2015.01.004 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Chen, Shaohua Zhang, Daohai Friend or foe: Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer |
title | Friend or foe: Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer |
title_full | Friend or foe: Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer |
title_fullStr | Friend or foe: Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer |
title_full_unstemmed | Friend or foe: Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer |
title_short | Friend or foe: Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer |
title_sort | friend or foe: endoplasmic reticulum protein 29 (erp29) in epithelial cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329646/ https://www.ncbi.nlm.nih.gov/pubmed/25709888 http://dx.doi.org/10.1016/j.fob.2015.01.004 |
work_keys_str_mv | AT chenshaohua friendorfoeendoplasmicreticulumprotein29erp29inepithelialcancer AT zhangdaohai friendorfoeendoplasmicreticulumprotein29erp29inepithelialcancer |