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Assays of different aspects of haemostasis – what do they measure?

Haemostasis is a complex process affected by many factors including both cellular and plasma components. It is a multistep process starting with platelet adhesion to damaged endothelium and ending in clot fibrinolysis. There are several methods available to study different aspects of haemostasis inc...

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Autores principales: Tynngård, Nahreen, Lindahl, Tomas L, Ramström, Sofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329663/
https://www.ncbi.nlm.nih.gov/pubmed/25688179
http://dx.doi.org/10.1186/s12959-015-0036-2
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author Tynngård, Nahreen
Lindahl, Tomas L
Ramström, Sofia
author_facet Tynngård, Nahreen
Lindahl, Tomas L
Ramström, Sofia
author_sort Tynngård, Nahreen
collection PubMed
description Haemostasis is a complex process affected by many factors including both cellular and plasma components. It is a multistep process starting with platelet adhesion to damaged endothelium and ending in clot fibrinolysis. There are several methods available to study different aspects of haemostasis including adhesion, aggregation, coagulation and fibrinolysis. This review describes the different methods, what aspects of haemostasis they measure and their limitations. Methods discussed include methods to study adhesion (e.g. PFA-100, cone and platelet(let) analyzer and perfusion chambers) and aggregation (e.g. Multiplate, VerifyNow and Plateletworks). Furthermore the principles behind viscoelastic haemostatic assays are presented as well as methods that can analyse aspects of haemostasis in plasma or platelet-rich-plasma samples (thrombin generation, overall haemostasis potential and Thrombodynamics Analyzer).
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spelling pubmed-43296632015-02-17 Assays of different aspects of haemostasis – what do they measure? Tynngård, Nahreen Lindahl, Tomas L Ramström, Sofia Thromb J Review Haemostasis is a complex process affected by many factors including both cellular and plasma components. It is a multistep process starting with platelet adhesion to damaged endothelium and ending in clot fibrinolysis. There are several methods available to study different aspects of haemostasis including adhesion, aggregation, coagulation and fibrinolysis. This review describes the different methods, what aspects of haemostasis they measure and their limitations. Methods discussed include methods to study adhesion (e.g. PFA-100, cone and platelet(let) analyzer and perfusion chambers) and aggregation (e.g. Multiplate, VerifyNow and Plateletworks). Furthermore the principles behind viscoelastic haemostatic assays are presented as well as methods that can analyse aspects of haemostasis in plasma or platelet-rich-plasma samples (thrombin generation, overall haemostasis potential and Thrombodynamics Analyzer). BioMed Central 2015-02-05 /pmc/articles/PMC4329663/ /pubmed/25688179 http://dx.doi.org/10.1186/s12959-015-0036-2 Text en © Tynngård et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Tynngård, Nahreen
Lindahl, Tomas L
Ramström, Sofia
Assays of different aspects of haemostasis – what do they measure?
title Assays of different aspects of haemostasis – what do they measure?
title_full Assays of different aspects of haemostasis – what do they measure?
title_fullStr Assays of different aspects of haemostasis – what do they measure?
title_full_unstemmed Assays of different aspects of haemostasis – what do they measure?
title_short Assays of different aspects of haemostasis – what do they measure?
title_sort assays of different aspects of haemostasis – what do they measure?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329663/
https://www.ncbi.nlm.nih.gov/pubmed/25688179
http://dx.doi.org/10.1186/s12959-015-0036-2
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