Cargando…
Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis
Invasive aspergillosis (IA) is a life-threatening infection due to Aspergillus fumigatus and other Aspergillus spp. Drugs targeting the fungal cell membrane (triazoles, amphotericin B) or cell wall (echinocandins) are currently the sole therapeutic options against IA. Their limited efficacy and the...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329796/ https://www.ncbi.nlm.nih.gov/pubmed/25762988 http://dx.doi.org/10.3389/fmicb.2015.00096 |
_version_ | 1782357492924153856 |
---|---|
author | Lamoth, Frédéric Juvvadi, Praveen R. Steinbach, William J. |
author_facet | Lamoth, Frédéric Juvvadi, Praveen R. Steinbach, William J. |
author_sort | Lamoth, Frédéric |
collection | PubMed |
description | Invasive aspergillosis (IA) is a life-threatening infection due to Aspergillus fumigatus and other Aspergillus spp. Drugs targeting the fungal cell membrane (triazoles, amphotericin B) or cell wall (echinocandins) are currently the sole therapeutic options against IA. Their limited efficacy and the emergence of resistance warrant the identification of new antifungal targets. Histone deacetylases (HDACs) are enzymes responsible of the deacetylation of lysine residues of core histones, thus controlling chromatin remodeling and transcriptional activation. HDACs also control the acetylation and activation status of multiple non-histone proteins, including the heat shock protein 90 (Hsp90), an essential molecular chaperone for fungal virulence and antifungal resistance. This review provides an overview of the different HDACs in Aspergillus spp. as well as their respective contribution to total HDAC activity, fungal growth, stress responses, and virulence. The potential of HDAC inhibitors, currently under development for cancer therapy, as novel alternative antifungal agents against IA is discussed. |
format | Online Article Text |
id | pubmed-4329796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-43297962015-03-11 Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis Lamoth, Frédéric Juvvadi, Praveen R. Steinbach, William J. Front Microbiol Microbiology Invasive aspergillosis (IA) is a life-threatening infection due to Aspergillus fumigatus and other Aspergillus spp. Drugs targeting the fungal cell membrane (triazoles, amphotericin B) or cell wall (echinocandins) are currently the sole therapeutic options against IA. Their limited efficacy and the emergence of resistance warrant the identification of new antifungal targets. Histone deacetylases (HDACs) are enzymes responsible of the deacetylation of lysine residues of core histones, thus controlling chromatin remodeling and transcriptional activation. HDACs also control the acetylation and activation status of multiple non-histone proteins, including the heat shock protein 90 (Hsp90), an essential molecular chaperone for fungal virulence and antifungal resistance. This review provides an overview of the different HDACs in Aspergillus spp. as well as their respective contribution to total HDAC activity, fungal growth, stress responses, and virulence. The potential of HDAC inhibitors, currently under development for cancer therapy, as novel alternative antifungal agents against IA is discussed. Frontiers Media S.A. 2015-02-16 /pmc/articles/PMC4329796/ /pubmed/25762988 http://dx.doi.org/10.3389/fmicb.2015.00096 Text en Copyright © 2015 Lamoth, Juvvadi and Steinbach. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Lamoth, Frédéric Juvvadi, Praveen R. Steinbach, William J. Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis |
title | Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis |
title_full | Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis |
title_fullStr | Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis |
title_full_unstemmed | Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis |
title_short | Histone deacetylase inhibition as an alternative strategy against invasive aspergillosis |
title_sort | histone deacetylase inhibition as an alternative strategy against invasive aspergillosis |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329796/ https://www.ncbi.nlm.nih.gov/pubmed/25762988 http://dx.doi.org/10.3389/fmicb.2015.00096 |
work_keys_str_mv | AT lamothfrederic histonedeacetylaseinhibitionasanalternativestrategyagainstinvasiveaspergillosis AT juvvadipraveenr histonedeacetylaseinhibitionasanalternativestrategyagainstinvasiveaspergillosis AT steinbachwilliamj histonedeacetylaseinhibitionasanalternativestrategyagainstinvasiveaspergillosis |