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Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction?

Early heart failure with preserved ejection fraction (HFpEF) is a frequent disease, but its diagnosis is difficult and relies mostly on the evidence of left ventricular filling pressure (LVFP) elevation during exercise. Several reports have suggested that natriuretic peptides plasma levels reflect e...

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Detalles Bibliográficos
Autores principales: Meluzín, Jaroslav, Tomandl, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329823/
https://www.ncbi.nlm.nih.gov/pubmed/25802475
http://dx.doi.org/10.1155/2015/426045
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author Meluzín, Jaroslav
Tomandl, Josef
author_facet Meluzín, Jaroslav
Tomandl, Josef
author_sort Meluzín, Jaroslav
collection PubMed
description Early heart failure with preserved ejection fraction (HFpEF) is a frequent disease, but its diagnosis is difficult and relies mostly on the evidence of left ventricular filling pressure (LVFP) elevation during exercise. Several reports have suggested that natriuretic peptides plasma levels reflect exercise-induced increase in LVFP, but they still have significant limitations. In this context, any new laboratory biomarker that can accurately reflect LVFP elevation during exercise is desirable. Recently, cardiotrophin-1, soluble endoglin, ST2, growth differentiation factor 15, galectin-3, and other new laboratory markers associated with LVFP have emerged. However, the current data on the relationship of these biomarkers and diastolic dysfunction are limited to resting conditions. Therefore, their secretion deserves to be tested under the exercise to determine their potential role in making a diagnosis of early HFpEF.
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spelling pubmed-43298232015-03-23 Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction? Meluzín, Jaroslav Tomandl, Josef Dis Markers Review Article Early heart failure with preserved ejection fraction (HFpEF) is a frequent disease, but its diagnosis is difficult and relies mostly on the evidence of left ventricular filling pressure (LVFP) elevation during exercise. Several reports have suggested that natriuretic peptides plasma levels reflect exercise-induced increase in LVFP, but they still have significant limitations. In this context, any new laboratory biomarker that can accurately reflect LVFP elevation during exercise is desirable. Recently, cardiotrophin-1, soluble endoglin, ST2, growth differentiation factor 15, galectin-3, and other new laboratory markers associated with LVFP have emerged. However, the current data on the relationship of these biomarkers and diastolic dysfunction are limited to resting conditions. Therefore, their secretion deserves to be tested under the exercise to determine their potential role in making a diagnosis of early HFpEF. Hindawi Publishing Corporation 2015 2015-01-31 /pmc/articles/PMC4329823/ /pubmed/25802475 http://dx.doi.org/10.1155/2015/426045 Text en Copyright © 2015 J. Meluzín and J. Tomandl. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Meluzín, Jaroslav
Tomandl, Josef
Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction?
title Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction?
title_full Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction?
title_fullStr Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction?
title_full_unstemmed Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction?
title_short Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction?
title_sort can biomarkers help to diagnose early heart failure with preserved ejection fraction?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329823/
https://www.ncbi.nlm.nih.gov/pubmed/25802475
http://dx.doi.org/10.1155/2015/426045
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