Cargando…
Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction?
Early heart failure with preserved ejection fraction (HFpEF) is a frequent disease, but its diagnosis is difficult and relies mostly on the evidence of left ventricular filling pressure (LVFP) elevation during exercise. Several reports have suggested that natriuretic peptides plasma levels reflect e...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329823/ https://www.ncbi.nlm.nih.gov/pubmed/25802475 http://dx.doi.org/10.1155/2015/426045 |
_version_ | 1782357499956953088 |
---|---|
author | Meluzín, Jaroslav Tomandl, Josef |
author_facet | Meluzín, Jaroslav Tomandl, Josef |
author_sort | Meluzín, Jaroslav |
collection | PubMed |
description | Early heart failure with preserved ejection fraction (HFpEF) is a frequent disease, but its diagnosis is difficult and relies mostly on the evidence of left ventricular filling pressure (LVFP) elevation during exercise. Several reports have suggested that natriuretic peptides plasma levels reflect exercise-induced increase in LVFP, but they still have significant limitations. In this context, any new laboratory biomarker that can accurately reflect LVFP elevation during exercise is desirable. Recently, cardiotrophin-1, soluble endoglin, ST2, growth differentiation factor 15, galectin-3, and other new laboratory markers associated with LVFP have emerged. However, the current data on the relationship of these biomarkers and diastolic dysfunction are limited to resting conditions. Therefore, their secretion deserves to be tested under the exercise to determine their potential role in making a diagnosis of early HFpEF. |
format | Online Article Text |
id | pubmed-4329823 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43298232015-03-23 Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction? Meluzín, Jaroslav Tomandl, Josef Dis Markers Review Article Early heart failure with preserved ejection fraction (HFpEF) is a frequent disease, but its diagnosis is difficult and relies mostly on the evidence of left ventricular filling pressure (LVFP) elevation during exercise. Several reports have suggested that natriuretic peptides plasma levels reflect exercise-induced increase in LVFP, but they still have significant limitations. In this context, any new laboratory biomarker that can accurately reflect LVFP elevation during exercise is desirable. Recently, cardiotrophin-1, soluble endoglin, ST2, growth differentiation factor 15, galectin-3, and other new laboratory markers associated with LVFP have emerged. However, the current data on the relationship of these biomarkers and diastolic dysfunction are limited to resting conditions. Therefore, their secretion deserves to be tested under the exercise to determine their potential role in making a diagnosis of early HFpEF. Hindawi Publishing Corporation 2015 2015-01-31 /pmc/articles/PMC4329823/ /pubmed/25802475 http://dx.doi.org/10.1155/2015/426045 Text en Copyright © 2015 J. Meluzín and J. Tomandl. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Meluzín, Jaroslav Tomandl, Josef Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction? |
title | Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction? |
title_full | Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction? |
title_fullStr | Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction? |
title_full_unstemmed | Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction? |
title_short | Can Biomarkers Help to Diagnose Early Heart Failure with Preserved Ejection Fraction? |
title_sort | can biomarkers help to diagnose early heart failure with preserved ejection fraction? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329823/ https://www.ncbi.nlm.nih.gov/pubmed/25802475 http://dx.doi.org/10.1155/2015/426045 |
work_keys_str_mv | AT meluzinjaroslav canbiomarkershelptodiagnoseearlyheartfailurewithpreservedejectionfraction AT tomandljosef canbiomarkershelptodiagnoseearlyheartfailurewithpreservedejectionfraction |