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Impact of Plasma Epstein-Barr Virus-DNA and Tumor Volume on Prognosis of Locally Advanced Nasopharyngeal Carcinoma

This retrospective study aims to examine the association of plasma Epstein-Barr virus- (EBV-) DNA levels with the tumor volume and prognosis in patients with locally advanced nasopharyngeal carcinoma (NPC). A total of 165 patients with newly diagnosed locally advanced NPC were identified from Septem...

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Autores principales: Chen, Meng, Yin, Li, Wu, Jing, Gu, Jia-Jia, Jiang, Xue-Song, Wang, De-Jun, Zong, Dan, Guo, Chang, Zhu, Huan-Feng, Wu, Jian-Feng, He, Xia, Guo, Wen-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329840/
https://www.ncbi.nlm.nih.gov/pubmed/25802858
http://dx.doi.org/10.1155/2015/617949
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author Chen, Meng
Yin, Li
Wu, Jing
Gu, Jia-Jia
Jiang, Xue-Song
Wang, De-Jun
Zong, Dan
Guo, Chang
Zhu, Huan-Feng
Wu, Jian-Feng
He, Xia
Guo, Wen-Jie
author_facet Chen, Meng
Yin, Li
Wu, Jing
Gu, Jia-Jia
Jiang, Xue-Song
Wang, De-Jun
Zong, Dan
Guo, Chang
Zhu, Huan-Feng
Wu, Jian-Feng
He, Xia
Guo, Wen-Jie
author_sort Chen, Meng
collection PubMed
description This retrospective study aims to examine the association of plasma Epstein-Barr virus- (EBV-) DNA levels with the tumor volume and prognosis in patients with locally advanced nasopharyngeal carcinoma (NPC). A total of 165 patients with newly diagnosed locally advanced NPC were identified from September 2011 to July 2012. EBV-DNA was detected using fluorescence quantitative polymerase chain reaction (PCR) amplification. The tumor volume was calculated by the systematic summation method of computer software. The median copy number of plasma EBV-DNA before treatment was 3790 copies/mL. The median gross tumor volume of the primary nasopharyngeal tumor (GTVnx), the lymph node lesions (GTVnd), and the total GTV before treatment were 72.46, 23.26, and 106.25 cm(3), respectively; the EBV-DNA levels were significantly correlated with the GTVnd and the total GTV (P < 0.01). The 2-year overall survival (OS) rates in patients with positive and negative pretreatment plasma EBV-DNA were 100% and 98.4% (P = 1.000), and the disease-free survival (DFS) rates were 94.4% and 80.8% (P = 0.044), respectively. These results indicate that high pretreatment plasma EBV-DNA levels in patients with locally advanced NPC are associated with the degree of lymph node metastasis, tumor burden, and poor prognosis.
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spelling pubmed-43298402015-03-23 Impact of Plasma Epstein-Barr Virus-DNA and Tumor Volume on Prognosis of Locally Advanced Nasopharyngeal Carcinoma Chen, Meng Yin, Li Wu, Jing Gu, Jia-Jia Jiang, Xue-Song Wang, De-Jun Zong, Dan Guo, Chang Zhu, Huan-Feng Wu, Jian-Feng He, Xia Guo, Wen-Jie Biomed Res Int Clinical Study This retrospective study aims to examine the association of plasma Epstein-Barr virus- (EBV-) DNA levels with the tumor volume and prognosis in patients with locally advanced nasopharyngeal carcinoma (NPC). A total of 165 patients with newly diagnosed locally advanced NPC were identified from September 2011 to July 2012. EBV-DNA was detected using fluorescence quantitative polymerase chain reaction (PCR) amplification. The tumor volume was calculated by the systematic summation method of computer software. The median copy number of plasma EBV-DNA before treatment was 3790 copies/mL. The median gross tumor volume of the primary nasopharyngeal tumor (GTVnx), the lymph node lesions (GTVnd), and the total GTV before treatment were 72.46, 23.26, and 106.25 cm(3), respectively; the EBV-DNA levels were significantly correlated with the GTVnd and the total GTV (P < 0.01). The 2-year overall survival (OS) rates in patients with positive and negative pretreatment plasma EBV-DNA were 100% and 98.4% (P = 1.000), and the disease-free survival (DFS) rates were 94.4% and 80.8% (P = 0.044), respectively. These results indicate that high pretreatment plasma EBV-DNA levels in patients with locally advanced NPC are associated with the degree of lymph node metastasis, tumor burden, and poor prognosis. Hindawi Publishing Corporation 2015 2015-01-31 /pmc/articles/PMC4329840/ /pubmed/25802858 http://dx.doi.org/10.1155/2015/617949 Text en Copyright © 2015 Meng Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Chen, Meng
Yin, Li
Wu, Jing
Gu, Jia-Jia
Jiang, Xue-Song
Wang, De-Jun
Zong, Dan
Guo, Chang
Zhu, Huan-Feng
Wu, Jian-Feng
He, Xia
Guo, Wen-Jie
Impact of Plasma Epstein-Barr Virus-DNA and Tumor Volume on Prognosis of Locally Advanced Nasopharyngeal Carcinoma
title Impact of Plasma Epstein-Barr Virus-DNA and Tumor Volume on Prognosis of Locally Advanced Nasopharyngeal Carcinoma
title_full Impact of Plasma Epstein-Barr Virus-DNA and Tumor Volume on Prognosis of Locally Advanced Nasopharyngeal Carcinoma
title_fullStr Impact of Plasma Epstein-Barr Virus-DNA and Tumor Volume on Prognosis of Locally Advanced Nasopharyngeal Carcinoma
title_full_unstemmed Impact of Plasma Epstein-Barr Virus-DNA and Tumor Volume on Prognosis of Locally Advanced Nasopharyngeal Carcinoma
title_short Impact of Plasma Epstein-Barr Virus-DNA and Tumor Volume on Prognosis of Locally Advanced Nasopharyngeal Carcinoma
title_sort impact of plasma epstein-barr virus-dna and tumor volume on prognosis of locally advanced nasopharyngeal carcinoma
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329840/
https://www.ncbi.nlm.nih.gov/pubmed/25802858
http://dx.doi.org/10.1155/2015/617949
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