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The Biocompatibility of Degradable Magnesium Interference Screws: An Experimental Study with Sheep
Screws for ligament reconstruction are nowadays mostly made of poly-L-lactide (PLLA). However, magnesium-based biomaterials are gathering increased interest in this research field because of their good mechanical property and osteoanabolic influence on bone metabolism. The aim of this pilot study wa...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329844/ https://www.ncbi.nlm.nih.gov/pubmed/25717474 http://dx.doi.org/10.1155/2015/943603 |
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author | Thormann, Ulrich Alt, Volker Heimann, Lydia Gasquere, Cyrille Heiss, Christian Szalay, Gabor Franke, Jörg Schnettler, Reinhard Lips, Katrin Susanne |
author_facet | Thormann, Ulrich Alt, Volker Heimann, Lydia Gasquere, Cyrille Heiss, Christian Szalay, Gabor Franke, Jörg Schnettler, Reinhard Lips, Katrin Susanne |
author_sort | Thormann, Ulrich |
collection | PubMed |
description | Screws for ligament reconstruction are nowadays mostly made of poly-L-lactide (PLLA). However, magnesium-based biomaterials are gathering increased interest in this research field because of their good mechanical property and osteoanabolic influence on bone metabolism. The aim of this pilot study was to evaluate the biocompatibility of an interference screw for ligament reconstruction made of magnesium alloy W4 by diecasting and milling and using different PEO-coatings with calcium phosphates. PLLA and titanium screws were used as control samples. The screws were implanted in the femur condyle of the hind leg of a merino sheep. The observation period was six and twelve weeks and one year. Histomorphometric, immunohistochemical, immunofluorescence, and molecular biological evaluation were conducted. Further TEM analysis was done. In all magnesium screws a clinically relevant gas formation in the vicinity of the biomaterial was observed. Except for the PLLA and titanium control samples, no screw was fully integrated in the surrounding bone tissue. Regarding the fabrication process, milling seems to produce less gas liberation and has a better influence on bone metabolism than diecasting. Coating by PEO with calcium phosphates could not reduce the initial gas liberation but rather reduced the bone metabolism in the vicinity of the biomaterial. |
format | Online Article Text |
id | pubmed-4329844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43298442015-02-25 The Biocompatibility of Degradable Magnesium Interference Screws: An Experimental Study with Sheep Thormann, Ulrich Alt, Volker Heimann, Lydia Gasquere, Cyrille Heiss, Christian Szalay, Gabor Franke, Jörg Schnettler, Reinhard Lips, Katrin Susanne Biomed Res Int Research Article Screws for ligament reconstruction are nowadays mostly made of poly-L-lactide (PLLA). However, magnesium-based biomaterials are gathering increased interest in this research field because of their good mechanical property and osteoanabolic influence on bone metabolism. The aim of this pilot study was to evaluate the biocompatibility of an interference screw for ligament reconstruction made of magnesium alloy W4 by diecasting and milling and using different PEO-coatings with calcium phosphates. PLLA and titanium screws were used as control samples. The screws were implanted in the femur condyle of the hind leg of a merino sheep. The observation period was six and twelve weeks and one year. Histomorphometric, immunohistochemical, immunofluorescence, and molecular biological evaluation were conducted. Further TEM analysis was done. In all magnesium screws a clinically relevant gas formation in the vicinity of the biomaterial was observed. Except for the PLLA and titanium control samples, no screw was fully integrated in the surrounding bone tissue. Regarding the fabrication process, milling seems to produce less gas liberation and has a better influence on bone metabolism than diecasting. Coating by PEO with calcium phosphates could not reduce the initial gas liberation but rather reduced the bone metabolism in the vicinity of the biomaterial. Hindawi Publishing Corporation 2015 2015-01-31 /pmc/articles/PMC4329844/ /pubmed/25717474 http://dx.doi.org/10.1155/2015/943603 Text en Copyright © 2015 Ulrich Thormann et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Thormann, Ulrich Alt, Volker Heimann, Lydia Gasquere, Cyrille Heiss, Christian Szalay, Gabor Franke, Jörg Schnettler, Reinhard Lips, Katrin Susanne The Biocompatibility of Degradable Magnesium Interference Screws: An Experimental Study with Sheep |
title | The Biocompatibility of Degradable Magnesium Interference Screws: An Experimental Study with Sheep |
title_full | The Biocompatibility of Degradable Magnesium Interference Screws: An Experimental Study with Sheep |
title_fullStr | The Biocompatibility of Degradable Magnesium Interference Screws: An Experimental Study with Sheep |
title_full_unstemmed | The Biocompatibility of Degradable Magnesium Interference Screws: An Experimental Study with Sheep |
title_short | The Biocompatibility of Degradable Magnesium Interference Screws: An Experimental Study with Sheep |
title_sort | biocompatibility of degradable magnesium interference screws: an experimental study with sheep |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329844/ https://www.ncbi.nlm.nih.gov/pubmed/25717474 http://dx.doi.org/10.1155/2015/943603 |
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