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Immunohistological Analysis of ABCD3 Expression in Caucasian and African American Prostate Tumors

In a previously published study, we showed that expression of the ABCD3 gene increased with increasing metastatic potential in a panel of prostate cancer cell lines derived from African American and Caucasian American men. Given importance of identifying biomarker(s) that can distinguish indolent ve...

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Autores principales: Reams, R. Renee, Jones-Triche, Jacqueline, Chan, Owen T. M., Hernandez, Brenda Y., Soliman, Karam F. A., Yates, Clayton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329846/
https://www.ncbi.nlm.nih.gov/pubmed/25802834
http://dx.doi.org/10.1155/2015/132981
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author Reams, R. Renee
Jones-Triche, Jacqueline
Chan, Owen T. M.
Hernandez, Brenda Y.
Soliman, Karam F. A.
Yates, Clayton
author_facet Reams, R. Renee
Jones-Triche, Jacqueline
Chan, Owen T. M.
Hernandez, Brenda Y.
Soliman, Karam F. A.
Yates, Clayton
author_sort Reams, R. Renee
collection PubMed
description In a previously published study, we showed that expression of the ABCD3 gene increased with increasing metastatic potential in a panel of prostate cancer cell lines derived from African American and Caucasian American men. Given importance of identifying biomarker(s) that can distinguish indolent versus aggressive prostate tumors, we conducted an immunohistochemical analysis of ABCD3 expression Caucasian and African American prostate tumors. ABCD3 expression in each patient population was compared with clinicopathologic characteristics, Gleason score, and age. ABCD3 expression increased with increasing Gleason score (P = 0.0094), age (P = 0.0014), and pathology grade (P = 0.0007) in Caucasian patients. Interestingly, in the AA patients, ABCD3 expression highly increased to the same degree in both low and high Gleason score tumors. Similarly, ABCD3 expression was elevated to the same degree in BPH derived from AA. Our findings demonstrate that increased ABCD3 expression correlates with Gleason Score in CA prostate tumors. However, in AA prostate tumors, ABCD3 expression was higher and was sustained in both low Gleason and high Gleason AA tumors. While the functional role of ABCD3 in prostate cancer is not completely elucidated, this gene warrants further study as a potential biomarker for aggressive prostate.
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spelling pubmed-43298462015-03-23 Immunohistological Analysis of ABCD3 Expression in Caucasian and African American Prostate Tumors Reams, R. Renee Jones-Triche, Jacqueline Chan, Owen T. M. Hernandez, Brenda Y. Soliman, Karam F. A. Yates, Clayton Biomed Res Int Research Article In a previously published study, we showed that expression of the ABCD3 gene increased with increasing metastatic potential in a panel of prostate cancer cell lines derived from African American and Caucasian American men. Given importance of identifying biomarker(s) that can distinguish indolent versus aggressive prostate tumors, we conducted an immunohistochemical analysis of ABCD3 expression Caucasian and African American prostate tumors. ABCD3 expression in each patient population was compared with clinicopathologic characteristics, Gleason score, and age. ABCD3 expression increased with increasing Gleason score (P = 0.0094), age (P = 0.0014), and pathology grade (P = 0.0007) in Caucasian patients. Interestingly, in the AA patients, ABCD3 expression highly increased to the same degree in both low and high Gleason score tumors. Similarly, ABCD3 expression was elevated to the same degree in BPH derived from AA. Our findings demonstrate that increased ABCD3 expression correlates with Gleason Score in CA prostate tumors. However, in AA prostate tumors, ABCD3 expression was higher and was sustained in both low Gleason and high Gleason AA tumors. While the functional role of ABCD3 in prostate cancer is not completely elucidated, this gene warrants further study as a potential biomarker for aggressive prostate. Hindawi Publishing Corporation 2015 2015-01-31 /pmc/articles/PMC4329846/ /pubmed/25802834 http://dx.doi.org/10.1155/2015/132981 Text en Copyright © 2015 R. Renee Reams et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Reams, R. Renee
Jones-Triche, Jacqueline
Chan, Owen T. M.
Hernandez, Brenda Y.
Soliman, Karam F. A.
Yates, Clayton
Immunohistological Analysis of ABCD3 Expression in Caucasian and African American Prostate Tumors
title Immunohistological Analysis of ABCD3 Expression in Caucasian and African American Prostate Tumors
title_full Immunohistological Analysis of ABCD3 Expression in Caucasian and African American Prostate Tumors
title_fullStr Immunohistological Analysis of ABCD3 Expression in Caucasian and African American Prostate Tumors
title_full_unstemmed Immunohistological Analysis of ABCD3 Expression in Caucasian and African American Prostate Tumors
title_short Immunohistological Analysis of ABCD3 Expression in Caucasian and African American Prostate Tumors
title_sort immunohistological analysis of abcd3 expression in caucasian and african american prostate tumors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329846/
https://www.ncbi.nlm.nih.gov/pubmed/25802834
http://dx.doi.org/10.1155/2015/132981
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