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Gender-Specific Associations of Serum Antibody to Porphyromonas gingivalis and Inflammatory Markers

It remains unclear whether serum antibody titer against Porphyromonas gingivalis (Pg) and inflammatory components lead to periodontal deterioration in each gender, as periodontal and systemic status is influenced by gender. The present study investigates the gender-specific probable effects of titer...

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Autores principales: Furuta, Michiko, Shimazaki, Yoshihiro, Tanaka, Shunichi, Takeuchi, Kenji, Shibata, Yukie, Takeshita, Toru, Nishimura, Fusanori, Yamashita, Yoshihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329867/
https://www.ncbi.nlm.nih.gov/pubmed/25756052
http://dx.doi.org/10.1155/2015/897971
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author Furuta, Michiko
Shimazaki, Yoshihiro
Tanaka, Shunichi
Takeuchi, Kenji
Shibata, Yukie
Takeshita, Toru
Nishimura, Fusanori
Yamashita, Yoshihisa
author_facet Furuta, Michiko
Shimazaki, Yoshihiro
Tanaka, Shunichi
Takeuchi, Kenji
Shibata, Yukie
Takeshita, Toru
Nishimura, Fusanori
Yamashita, Yoshihisa
author_sort Furuta, Michiko
collection PubMed
description It remains unclear whether serum antibody titer against Porphyromonas gingivalis (Pg) and inflammatory components lead to periodontal deterioration in each gender, as periodontal and systemic status is influenced by gender. The present study investigates the gender-specific probable effects of titer against Pg and inflammatory markers on periodontal health status in a longitudinal study. A retrospective study design was used. At two time points over an 8-year period (in 2003 and 2011), 411 individuals (295 males with a mean age of 57.6 ± 11.2 years and 116 females with a mean age of 59.2 ± 10.3 years) were surveyed. Periodontal status, serum antibody titer against Pg, and high-sensitive C-reactive protein (hsCRP) were evaluated. Poisson regression analyses revealed that the elevated titer against Pg and hsCRP significantly predicted the persistence of periodontal disease 8 years later in females with periodontal disease in 2003. Elevated hsCRP was significantly associated with the incidence of periodontal disease 8 years later in females who were periodontally healthy in 2003. Males had a weaker association among titer against Pg, inflammatory markers, and periodontal disease. These findings suggest that immune response to Pg infection in addition to inflammatory components affects periodontal deterioration in females.
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spelling pubmed-43298672015-03-09 Gender-Specific Associations of Serum Antibody to Porphyromonas gingivalis and Inflammatory Markers Furuta, Michiko Shimazaki, Yoshihiro Tanaka, Shunichi Takeuchi, Kenji Shibata, Yukie Takeshita, Toru Nishimura, Fusanori Yamashita, Yoshihisa Biomed Res Int Research Article It remains unclear whether serum antibody titer against Porphyromonas gingivalis (Pg) and inflammatory components lead to periodontal deterioration in each gender, as periodontal and systemic status is influenced by gender. The present study investigates the gender-specific probable effects of titer against Pg and inflammatory markers on periodontal health status in a longitudinal study. A retrospective study design was used. At two time points over an 8-year period (in 2003 and 2011), 411 individuals (295 males with a mean age of 57.6 ± 11.2 years and 116 females with a mean age of 59.2 ± 10.3 years) were surveyed. Periodontal status, serum antibody titer against Pg, and high-sensitive C-reactive protein (hsCRP) were evaluated. Poisson regression analyses revealed that the elevated titer against Pg and hsCRP significantly predicted the persistence of periodontal disease 8 years later in females with periodontal disease in 2003. Elevated hsCRP was significantly associated with the incidence of periodontal disease 8 years later in females who were periodontally healthy in 2003. Males had a weaker association among titer against Pg, inflammatory markers, and periodontal disease. These findings suggest that immune response to Pg infection in addition to inflammatory components affects periodontal deterioration in females. Hindawi Publishing Corporation 2015 2015-01-31 /pmc/articles/PMC4329867/ /pubmed/25756052 http://dx.doi.org/10.1155/2015/897971 Text en Copyright © 2015 Michiko Furuta et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Furuta, Michiko
Shimazaki, Yoshihiro
Tanaka, Shunichi
Takeuchi, Kenji
Shibata, Yukie
Takeshita, Toru
Nishimura, Fusanori
Yamashita, Yoshihisa
Gender-Specific Associations of Serum Antibody to Porphyromonas gingivalis and Inflammatory Markers
title Gender-Specific Associations of Serum Antibody to Porphyromonas gingivalis and Inflammatory Markers
title_full Gender-Specific Associations of Serum Antibody to Porphyromonas gingivalis and Inflammatory Markers
title_fullStr Gender-Specific Associations of Serum Antibody to Porphyromonas gingivalis and Inflammatory Markers
title_full_unstemmed Gender-Specific Associations of Serum Antibody to Porphyromonas gingivalis and Inflammatory Markers
title_short Gender-Specific Associations of Serum Antibody to Porphyromonas gingivalis and Inflammatory Markers
title_sort gender-specific associations of serum antibody to porphyromonas gingivalis and inflammatory markers
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329867/
https://www.ncbi.nlm.nih.gov/pubmed/25756052
http://dx.doi.org/10.1155/2015/897971
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