Cargando…

Pharmacogenomics of Hypertension: A Genome‐Wide, Placebo‐Controlled Cross‐Over Study, Using Four Classes of Antihypertensive Drugs

BACKGROUND: Identification of genetic markers of antihypertensive drug responses could assist in individualization of hypertension treatment. METHODS AND RESULTS: We conducted a genome‐wide association study to identify gene loci influencing the responsiveness of 228 male patients to 4 classes of an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hiltunen, Timo P., Donner, Kati M., Sarin, Antti‐Pekka, Saarela, Janna, Ripatti, Samuli, Chapman, Arlene B., Gums, John G., Gong, Yan, Cooper‐DeHoff, Rhonda M., Frau, Francesca, Glorioso, Valeria, Zaninello, Roberta, Salvi, Erika, Glorioso, Nicola, Boerwinkle, Eric, Turner, Stephen T., Johnson, Julie A., Kontula, Kimmo K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330076/ https://www.ncbi.nlm.nih.gov/pubmed/25622599 http://dx.doi.org/10.1161/JAHA.114.001521

Ejemplares similares

Genome‐Wide Meta‐Analysis of Blood Pressure Response to β(1)‐Blockers: Results From ICAPS (International Consortium of Antihypertensive Pharmacogenomics Studies)
por: Singh, Sonal, et al.
Publicado: (2019)

Human essential hypertension: no significant association of polygenic risk scores with antihypertensive drug responses
por: Sánez Tähtisalo, Heini, et al.
Publicado: (2020)

Genetic Variants Associated With Uncontrolled Blood Pressure on Thiazide Diuretic/β‐Blocker Combination Therapy in the PEAR (Pharmacogenomic Evaluation of Antihypertensive Responses) and INVEST (International Verapamil‐SR Trandolapril Study) Trials
por: Magvanjav, Oyunbileg, et al.
Publicado: (2017)

Power to identify a genetic predictor of antihypertensive drug response using different methods to measure blood pressure response
por: Turner, Stephen T, et al.
Publicado: (2012)

Atenolol Induced HDL-C Change in the Pharmacogenomic Evaluation of Antihypertensive Responses (PEAR) Study
por: McDonough, Caitrin W., et al.
Publicado: (2013)

Pharmacoepigenetics of hypertension: genome-wide methylation analysis of responsiveness to four classes of antihypertensive drugs using a double-blind crossover study design
por: Nuotio, Marja-Liisa, et al.
Publicado: (2022)

Association of Chromosome 12 locus with antihypertensive response to hydrochlorothiazide may involve differential YEATS4 expression
por: Duarte, Julio D., et al.
Publicado: (2012)

Effects of four different antihypertensive drugs on plasma metabolomic profiles in patients with essential hypertension
por: Hiltunen, Timo P., et al.
Publicado: (2017)

Effect of four classes of antihypertensive drugs on cardiac repolarization heterogeneity: A double-blind rotational study
por: Sánez Tähtisalo, Heini, et al.
Publicado: (2020)

Pairwise comparison of hydrochlorothiazide and chlorthalidone responses among hypertensive patients
por: Chekka, Lakshmi Manasa S., et al.
Publicado: (2022)

Genome-Wide Association Study Identifies Pharmacogenomic Loci Linked with Specific Antihypertensive Drug Treatment and New-Onset Diabetes
por: Chang, Shin-Wen, et al.
Publicado: (2016)

Genome Wide Analysis Approach Suggests Chromosome 2 Locus to be Associated with Thiazide and Thiazide Like-Diuretics Blood Pressure Response
por: Singh, Sonal, et al.
Publicado: (2019)

Antihypertensive Drug Class Interactions and Risk for Incident Diabetes: A Nested Case–Control Study
por: Cooper‐DeHoff, Rhonda M., et al.
Publicado: (2013)

Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers
por: Cunningham, Patrick N., et al.
Publicado: (2019)

Optimizing Antihypertensive Medication Classification in Electronic Health Record-Based Data: Classification System Development and Methodological Comparison
por: McDonough, Caitrin W, et al.
Publicado: (2020)

Personalized antihypertensive treatment guided by pharmacogenomics in China
por: Xiao, Zhi-Lin, et al.
Publicado: (2022)

Genome‐Wide Association Approach Identified Novel Genetic Predictors of Heart Rate Response to β‐Blockers
por: Shahin, Mohamed H., et al.
Publicado: (2018)

Genomic Association Analysis Reveals Variants Associated With Blood Pressure Response to Beta‐Blockers in European Americans
por: Singh, Sonal, et al.
Publicado: (2019)

Influence of Genetic West African Ancestry on Metabolomics among Hypertensive Patients
por: Mehanna, Mai, et al.
Publicado: (2022)

A Functional 12T-Insertion Polymorphism in the ATP1A1 Promoter Confers Decreased Susceptibility to Hypertension in a Male Sardinian Population
por: Herrera, Victoria L., et al.
Publicado: (2015)

Comparing marginal structural models to standard methods for estimating treatment effects of antihypertensive combination therapy
por: Gerhard, Tobias, et al.
Publicado: (2012)

Sex-Specific Effects of NLRP6/AVR and ADM Loci on Susceptibility to Essential Hypertension in a Sardinian Population
por: Glorioso, Nicola, et al.
Publicado: (2013)

Metabolomics Signature of Plasma Renin Activity and Linkage with Blood Pressure Response to Beta Blockers and Thiazide Diuretics in Hypertensive European American Patients
por: Mehanna, Mai, et al.
Publicado: (2021)

“Alexa, please try to understand my accent”: reflections on the assumptions behind and expectations about Artificial Intelligence systems
por: Glorioso, Andrea
Publicado: (2020)

Impact of CYP2D6 polymorphisms on clinical efficacy & tolerability of metoprolol tartrate
por: Hamadeh, Issam S., et al.
Publicado: (2014)

Genome-wide association study of nocturnal blood pressure dipping in hypertensive patients
por: Rimpelä, Jenni M., et al.
Publicado: (2018)

Sardinians Genetic Background Explained by Runs of Homozygosity and Genomic Regions under Positive Selection
por: Di Gaetano, Cornelia, et al.
Publicado: (2014)

Engineering cybernetics
por: Glorioso, Robert M
Publicado: (1975)

Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide
por: Duarte, Julio D, et al.
Publicado: (2012)

Whole Transcriptome Sequencing Analyses Reveal Molecular Markers of Blood Pressure Response to Thiazide Diuretics
por: Sá, Ana Caroline C., et al.
Publicado: (2017)

Initial Antihypertensive Regimens in Newly Treated Patients: Real World Evidence From the OneFlorida+ Clinical Research Network
por: Smith, Steven M., et al.
Publicado: (2022)

Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics
por: Shahin, Mohamed H., et al.
Publicado: (2017)

Assessment of a Manual Method versus an Automated, Probability-Based Algorithm to Identify Patients at High Risk for Pharmacogenomic Adverse Drug Outcomes in a University-Based Health Insurance Program
por: Grande, Kendra J., et al.
Publicado: (2022)

Genetic Loci Associated with Allergic Sensitization in Lithuanians
por: Šaulienė, Ingrida, et al.
Publicado: (2015)

Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans
por: Del-Aguila, J L, et al.
Publicado: (2014)

Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies
por: Sá, Ana Caroline C., et al.
Publicado: (2018)

Medication Adherence—Still the Holy Grail
por: Cooper‐DeHoff, Rhonda M., et al.
Publicado: (2023)

Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium
por: Bis, Joshua C., et al.
Publicado: (2015)

Gender Differences in Genetic Risk Profiles for Cardiovascular Disease
por: Silander, Kaisa, et al.
Publicado: (2008)

Antihypertensive treatment guided by genetics: PEARL-HT, the randomized proof-of-concept trial comparing rostafuroxin with losartan
por: Citterio, Lorena, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_m1eqgkf3rqdc26008qrsmh89vt