Cargando…

Evaluation of Random Urine Sodium and Potassium Compensated by Creatinine as Possible Alternative Markers for 24 Hours Urinary Sodium and Potassium Excretion

Sodium and potassium intake was assessed on the basis of its respective excretion levels in 24 hr urine samples. However, owing to the inconvenience of collection, we evaluated random spot urine for alternative sodium and potassium excretion markers. We included 250 patients who submitted 24 hr- and...

Descripción completa

Detalles Bibliográficos
Autores principales: Koo, Hyunmin, Lee, Sang-Guk, Kim, Jeong-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Laboratory Medicine 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330175/
https://www.ncbi.nlm.nih.gov/pubmed/25729727
http://dx.doi.org/10.3343/alm.2015.35.2.238
_version_ 1782357543011483648
author Koo, Hyunmin
Lee, Sang-Guk
Kim, Jeong-Ho
author_facet Koo, Hyunmin
Lee, Sang-Guk
Kim, Jeong-Ho
author_sort Koo, Hyunmin
collection PubMed
description Sodium and potassium intake was assessed on the basis of its respective excretion levels in 24 hr urine samples. However, owing to the inconvenience of collection, we evaluated random spot urine for alternative sodium and potassium excretion markers. We included 250 patients who submitted 24 hr- and spot urine for clinical tests. However, 22 patients who showed 24 hr urine creatinine excretion levels <500 mg/day were excluded, because these samples possibly resulted from incomplete urine collection. Moreover, 24 patients were excluded because of their use of diuretics during the urine collection period. We observed significant correlations between 24 hr urine sodium excretion and both the sodium/creatinine (r=0.34, P<0.0001) and the sodium/specific gravity unit (SGU) ratios (r=0.19, P=0.007) in random urine samples. Similarly, 24 hr urine potassium excretion and both the spot urine potassium/creatinine (r=0.47, P<0.0001) and potassium/SGU ratios (r=0.28, P<0.0001) were significantly correlated. Although the estimated sodium/creatinine and potassium/creatinine ratios showed a significant correlation with 24 hr urine sodium and potassium excretion, respectively, further studies are required to develop a spot urine test for individualized monitoring of sodium and potassium excretion.
format Online
Article
Text
id pubmed-4330175
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher The Korean Society for Laboratory Medicine
record_format MEDLINE/PubMed
spelling pubmed-43301752015-03-01 Evaluation of Random Urine Sodium and Potassium Compensated by Creatinine as Possible Alternative Markers for 24 Hours Urinary Sodium and Potassium Excretion Koo, Hyunmin Lee, Sang-Guk Kim, Jeong-Ho Ann Lab Med Brief Communication Sodium and potassium intake was assessed on the basis of its respective excretion levels in 24 hr urine samples. However, owing to the inconvenience of collection, we evaluated random spot urine for alternative sodium and potassium excretion markers. We included 250 patients who submitted 24 hr- and spot urine for clinical tests. However, 22 patients who showed 24 hr urine creatinine excretion levels <500 mg/day were excluded, because these samples possibly resulted from incomplete urine collection. Moreover, 24 patients were excluded because of their use of diuretics during the urine collection period. We observed significant correlations between 24 hr urine sodium excretion and both the sodium/creatinine (r=0.34, P<0.0001) and the sodium/specific gravity unit (SGU) ratios (r=0.19, P=0.007) in random urine samples. Similarly, 24 hr urine potassium excretion and both the spot urine potassium/creatinine (r=0.47, P<0.0001) and potassium/SGU ratios (r=0.28, P<0.0001) were significantly correlated. Although the estimated sodium/creatinine and potassium/creatinine ratios showed a significant correlation with 24 hr urine sodium and potassium excretion, respectively, further studies are required to develop a spot urine test for individualized monitoring of sodium and potassium excretion. The Korean Society for Laboratory Medicine 2015-03 2015-02-12 /pmc/articles/PMC4330175/ /pubmed/25729727 http://dx.doi.org/10.3343/alm.2015.35.2.238 Text en © The Korean Society for Laboratory Medicine. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Koo, Hyunmin
Lee, Sang-Guk
Kim, Jeong-Ho
Evaluation of Random Urine Sodium and Potassium Compensated by Creatinine as Possible Alternative Markers for 24 Hours Urinary Sodium and Potassium Excretion
title Evaluation of Random Urine Sodium and Potassium Compensated by Creatinine as Possible Alternative Markers for 24 Hours Urinary Sodium and Potassium Excretion
title_full Evaluation of Random Urine Sodium and Potassium Compensated by Creatinine as Possible Alternative Markers for 24 Hours Urinary Sodium and Potassium Excretion
title_fullStr Evaluation of Random Urine Sodium and Potassium Compensated by Creatinine as Possible Alternative Markers for 24 Hours Urinary Sodium and Potassium Excretion
title_full_unstemmed Evaluation of Random Urine Sodium and Potassium Compensated by Creatinine as Possible Alternative Markers for 24 Hours Urinary Sodium and Potassium Excretion
title_short Evaluation of Random Urine Sodium and Potassium Compensated by Creatinine as Possible Alternative Markers for 24 Hours Urinary Sodium and Potassium Excretion
title_sort evaluation of random urine sodium and potassium compensated by creatinine as possible alternative markers for 24 hours urinary sodium and potassium excretion
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330175/
https://www.ncbi.nlm.nih.gov/pubmed/25729727
http://dx.doi.org/10.3343/alm.2015.35.2.238
work_keys_str_mv AT koohyunmin evaluationofrandomurinesodiumandpotassiumcompensatedbycreatinineaspossiblealternativemarkersfor24hoursurinarysodiumandpotassiumexcretion
AT leesangguk evaluationofrandomurinesodiumandpotassiumcompensatedbycreatinineaspossiblealternativemarkersfor24hoursurinarysodiumandpotassiumexcretion
AT kimjeongho evaluationofrandomurinesodiumandpotassiumcompensatedbycreatinineaspossiblealternativemarkersfor24hoursurinarysodiumandpotassiumexcretion