Genome-Wide Identification and Classification of MicroRNAs Derived from Repetitive Elements

MicroRNAs (miRNAs) are known for their role in mRNA silencing via interference pathways. Repetitive elements (REs) share several characteristics with endogenous precursor miRNAs. In this study, 406 previously identified and 1,494 novel RE-derived miRNAs were sorted from the GENCODE v.19 database usi...

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Detalles Bibliográficos
Autores principales: Gim, Jeong-An, Ha, Hong-Seok, Ahn, Kung, Kim, Dae-Soo, Kim, Heui-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korea Genome Organization 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330264/
https://www.ncbi.nlm.nih.gov/pubmed/25705168
http://dx.doi.org/10.5808/GI.2014.12.4.261
Descripción
Sumario:MicroRNAs (miRNAs) are known for their role in mRNA silencing via interference pathways. Repetitive elements (REs) share several characteristics with endogenous precursor miRNAs. In this study, 406 previously identified and 1,494 novel RE-derived miRNAs were sorted from the GENCODE v.19 database using the RepeatMasker program. They were divided into six major types, based on their genomic structure. More novel RE-derived miRNAs were confirmed than identified as RE-derived miRNAs. In conclusion, many miRNAs have not yet been identified, most of which are derived from REs.

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