Genome-Wide Identification and Classification of MicroRNAs Derived from Repetitive Elements

MicroRNAs (miRNAs) are known for their role in mRNA silencing via interference pathways. Repetitive elements (REs) share several characteristics with endogenous precursor miRNAs. In this study, 406 previously identified and 1,494 novel RE-derived miRNAs were sorted from the GENCODE v.19 database usi...

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Detalles Bibliográficos
Autores principales: Gim, Jeong-An, Ha, Hong-Seok, Ahn, Kung, Kim, Dae-Soo, Kim, Heui-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korea Genome Organization 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330264/
https://www.ncbi.nlm.nih.gov/pubmed/25705168
http://dx.doi.org/10.5808/GI.2014.12.4.261
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author Gim, Jeong-An
Ha, Hong-Seok
Ahn, Kung
Kim, Dae-Soo
Kim, Heui-Soo
author_facet Gim, Jeong-An
Ha, Hong-Seok
Ahn, Kung
Kim, Dae-Soo
Kim, Heui-Soo
author_sort Gim, Jeong-An
collection PubMed
description MicroRNAs (miRNAs) are known for their role in mRNA silencing via interference pathways. Repetitive elements (REs) share several characteristics with endogenous precursor miRNAs. In this study, 406 previously identified and 1,494 novel RE-derived miRNAs were sorted from the GENCODE v.19 database using the RepeatMasker program. They were divided into six major types, based on their genomic structure. More novel RE-derived miRNAs were confirmed than identified as RE-derived miRNAs. In conclusion, many miRNAs have not yet been identified, most of which are derived from REs.
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spelling pubmed-43302642015-02-22 Genome-Wide Identification and Classification of MicroRNAs Derived from Repetitive Elements Gim, Jeong-An Ha, Hong-Seok Ahn, Kung Kim, Dae-Soo Kim, Heui-Soo Genomics Inform Original Article MicroRNAs (miRNAs) are known for their role in mRNA silencing via interference pathways. Repetitive elements (REs) share several characteristics with endogenous precursor miRNAs. In this study, 406 previously identified and 1,494 novel RE-derived miRNAs were sorted from the GENCODE v.19 database using the RepeatMasker program. They were divided into six major types, based on their genomic structure. More novel RE-derived miRNAs were confirmed than identified as RE-derived miRNAs. In conclusion, many miRNAs have not yet been identified, most of which are derived from REs. Korea Genome Organization 2014-12 2014-12-31 /pmc/articles/PMC4330264/ /pubmed/25705168 http://dx.doi.org/10.5808/GI.2014.12.4.261 Text en Copyright © 2014 by the Korea Genome Organization http://creativecommons.org/licenses/by-nc/3.0/ It is identical to the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/).
spellingShingle Original Article
Gim, Jeong-An
Ha, Hong-Seok
Ahn, Kung
Kim, Dae-Soo
Kim, Heui-Soo
Genome-Wide Identification and Classification of MicroRNAs Derived from Repetitive Elements
title Genome-Wide Identification and Classification of MicroRNAs Derived from Repetitive Elements
title_full Genome-Wide Identification and Classification of MicroRNAs Derived from Repetitive Elements
title_fullStr Genome-Wide Identification and Classification of MicroRNAs Derived from Repetitive Elements
title_full_unstemmed Genome-Wide Identification and Classification of MicroRNAs Derived from Repetitive Elements
title_short Genome-Wide Identification and Classification of MicroRNAs Derived from Repetitive Elements
title_sort genome-wide identification and classification of micrornas derived from repetitive elements
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330264/
https://www.ncbi.nlm.nih.gov/pubmed/25705168
http://dx.doi.org/10.5808/GI.2014.12.4.261
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