The ATP binding site of the chromatin remodeling homolog Lsh is required for nucleosome density and de novo DNA methylation at repeat sequences

Lsh, a chromatin remodeling protein of the SNF2 family, is critical for normal heterochromatin structure. In particular, DNA methylation at repeat elements, a hallmark of heterochromatin, is greatly reduced in Lsh(−/−) (KO) cells. Here, we examined the presumed nucleosome remodeling activity of Lsh...

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Detalles Bibliográficos
Autores principales: Ren, Jianke, Briones, Victorino, Barbour, Samantha, Yu, Weishi, Han, Yixing, Terashima, Minoru, Muegge, Kathrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330352/
https://www.ncbi.nlm.nih.gov/pubmed/25578963
http://dx.doi.org/10.1093/nar/gku1371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330352/
https://www.ncbi.nlm.nih.gov/pubmed/25578963
http://dx.doi.org/10.1093/nar/gku1371

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