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DNA lesion identity drives choice of damage tolerance pathway in murine cell chromosomes

DNA-damage tolerance (DDT) via translesion DNA synthesis (TLS) or homology-dependent repair (HDR) functions to bypass DNA lesions encountered during replication, and is critical for maintaining genome stability. Here, we present piggyBlock, a new chromosomal assay that, using piggyBac transposition...

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Detalles Bibliográficos
Autores principales:	Cohen, Isadora S., Bar, Carmit, Paz-Elizur, Tamar, Ainbinder, Elena, Leopold, Karoline, de Wind, Niels, Geacintov, Nicholas, Livneh, Zvi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330363/ https://www.ncbi.nlm.nih.gov/pubmed/25589543 http://dx.doi.org/10.1093/nar/gku1398

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