A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells

Epigenetic silencing of transgene expression represents a major obstacle for the efficient genetic modification of multipotent and pluripotent stem cells. We and others have demonstrated that a 1.5 kb methylation-free CpG island from the human HNRPA2B1-CBX3 housekeeping genes (A2UCOE) effectively pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Müller-Kuller, Uta, Ackermann, Mania, Kolodziej, Stephan, Brendel, Christian, Fritsch, Jessica, Lachmann, Nico, Kunkel, Hana, Lausen, Jörn, Schambach, Axel, Moritz, Thomas, Grez, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330381/
https://www.ncbi.nlm.nih.gov/pubmed/25605798
http://dx.doi.org/10.1093/nar/gkv019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330381/
https://www.ncbi.nlm.nih.gov/pubmed/25605798
http://dx.doi.org/10.1093/nar/gkv019

Ejemplares similares