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A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells

Epigenetic silencing of transgene expression represents a major obstacle for the efficient genetic modification of multipotent and pluripotent stem cells. We and others have demonstrated that a 1.5 kb methylation-free CpG island from the human HNRPA2B1-CBX3 housekeeping genes (A2UCOE) effectively pr...

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Detalles Bibliográficos
Autores principales:	Müller-Kuller, Uta, Ackermann, Mania, Kolodziej, Stephan, Brendel, Christian, Fritsch, Jessica, Lachmann, Nico, Kunkel, Hana, Lausen, Jörn, Schambach, Axel, Moritz, Thomas, Grez, Manuel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330381/ https://www.ncbi.nlm.nih.gov/pubmed/25605798 http://dx.doi.org/10.1093/nar/gkv019

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