Structural basis for PPARγ transactivation by endocrine-disrupting organotin compounds

Organotin compounds such as triphenyltin (TPT) and tributyltin (TBT) act as endocrine disruptors through the peroxisome proliferator–activated receptor γ (PPARγ) signaling pathway. We recently found that TPT is a particularly strong agonist of PPARγ. To elucidate the mechanism underlying organotin-d...

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Detalles Bibliográficos
Autores principales: Harada, Shusaku, Hiromori, Youhei, Nakamura, Shota, Kawahara, Kazuki, Fukakusa, Shunsuke, Maruno, Takahiro, Noda, Masanori, Uchiyama, Susumu, Fukui, Kiichi, Nishikawa, Jun-ichi, Nagase, Hisamitsu, Kobayashi, Yuji, Yoshida, Takuya, Ohkubo, Tadayasu, Nakanishi, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330522/
https://www.ncbi.nlm.nih.gov/pubmed/25687586
http://dx.doi.org/10.1038/srep08520

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