MDR1 siRNA loaded hyaluronic acid-based CD44 targeted nanoparticle systems circumvent paclitaxel resistance in ovarian cancer

Development of multidrug resistance (MDR) is an almost universal phenomenon in patients with ovarian cancer, and this severely limits the ultimate success of chemotherapy in the clinic. Overexpression of the MDR1 gene and corresponding P-glycoprotein (Pgp) is one of the best known MDR mechanisms. MD...

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Detalles Bibliográficos
Autores principales: Yang, Xiaoqian, lyer, Arun K., Singh, Amit, Choy, Edwin, Hornicek, Francis J., Amiji, Mansoor M., Duan, Zhenfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330541/
https://www.ncbi.nlm.nih.gov/pubmed/25687880
http://dx.doi.org/10.1038/srep08509

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