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A lesson on induction of hypothermia and measurement of efficacy
Brain injuries caused by stroke are common and costly in human and resource terms. The result of stroke is a cascade of molecular and physiological derangement, cell death, damage and inflammation in the brain. This, together with infection, if present, commonly results in patients having an increas...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330594/ https://www.ncbi.nlm.nih.gov/pubmed/25672818 http://dx.doi.org/10.1186/s13054-014-0710-y |
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author | Harris, Bridget A Andrews, Peter JD |
author_facet | Harris, Bridget A Andrews, Peter JD |
author_sort | Harris, Bridget A |
collection | PubMed |
description | Brain injuries caused by stroke are common and costly in human and resource terms. The result of stroke is a cascade of molecular and physiological derangement, cell death, damage and inflammation in the brain. This, together with infection, if present, commonly results in patients having an increased temperature, which is associated with worse outcome. The usual clinical goal in stroke is therefore to reduce temperature to normal, or below normal (hypothermia) to reduce swelling if brain pressure is increased. However, research evidence does not yet conclusively show whether or not cooling patients after stroke improves their longer-term outcome (reduces death and disability). It is possible that complications of cooling outweigh the benefits. Cooling therapy may reduce damage and potentially improve outcome, and head cooling targets the site of injury and may have fewer side effects than systemic cooling, but the evidence base is unclear. |
format | Online Article Text |
id | pubmed-4330594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43305942015-02-18 A lesson on induction of hypothermia and measurement of efficacy Harris, Bridget A Andrews, Peter JD Crit Care Commentary Brain injuries caused by stroke are common and costly in human and resource terms. The result of stroke is a cascade of molecular and physiological derangement, cell death, damage and inflammation in the brain. This, together with infection, if present, commonly results in patients having an increased temperature, which is associated with worse outcome. The usual clinical goal in stroke is therefore to reduce temperature to normal, or below normal (hypothermia) to reduce swelling if brain pressure is increased. However, research evidence does not yet conclusively show whether or not cooling patients after stroke improves their longer-term outcome (reduces death and disability). It is possible that complications of cooling outweigh the benefits. Cooling therapy may reduce damage and potentially improve outcome, and head cooling targets the site of injury and may have fewer side effects than systemic cooling, but the evidence base is unclear. BioMed Central 2014-12-22 2014 /pmc/articles/PMC4330594/ /pubmed/25672818 http://dx.doi.org/10.1186/s13054-014-0710-y Text en © Harris and Andrews; licensee BioMed Central Ltd. 2014 The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Commentary Harris, Bridget A Andrews, Peter JD A lesson on induction of hypothermia and measurement of efficacy |
title | A lesson on induction of hypothermia and measurement of efficacy |
title_full | A lesson on induction of hypothermia and measurement of efficacy |
title_fullStr | A lesson on induction of hypothermia and measurement of efficacy |
title_full_unstemmed | A lesson on induction of hypothermia and measurement of efficacy |
title_short | A lesson on induction of hypothermia and measurement of efficacy |
title_sort | lesson on induction of hypothermia and measurement of efficacy |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330594/ https://www.ncbi.nlm.nih.gov/pubmed/25672818 http://dx.doi.org/10.1186/s13054-014-0710-y |
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