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Modeling circadian and sleep-homeostatic effects on short-term interval timing
Short-term interval timing i.e., perception and action relating to durations in the seconds range, has been suggested to display time-of-day as well as wake dependent fluctuations due to circadian and sleep-homeostatic changes to the rate at which an underlying pacemaker emits pulses; pertinent huma...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330698/ https://www.ncbi.nlm.nih.gov/pubmed/25741253 http://dx.doi.org/10.3389/fnint.2015.00015 |
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author | Späti, Jakub Aritake, Sayaka Meyer, Andrea H. Kitamura, Shingo Hida, Akiko Higuchi, Shigekazu Moriguchi, Yoshiya Mishima, Kazuo |
author_facet | Späti, Jakub Aritake, Sayaka Meyer, Andrea H. Kitamura, Shingo Hida, Akiko Higuchi, Shigekazu Moriguchi, Yoshiya Mishima, Kazuo |
author_sort | Späti, Jakub |
collection | PubMed |
description | Short-term interval timing i.e., perception and action relating to durations in the seconds range, has been suggested to display time-of-day as well as wake dependent fluctuations due to circadian and sleep-homeostatic changes to the rate at which an underlying pacemaker emits pulses; pertinent human data being relatively sparse and lacking in consistency however, the phenomenon remains elusive and its mechanism poorly understood. To better characterize the putative circadian and sleep-homeostatic effects on interval timing and to assess the ability of a pacemaker-based mechanism to account for the data, we measured timing performance in eighteen young healthy male subjects across two epochs of sustained wakefulness of 38.67 h each, conducted prior to (under entrained conditions) and following (under free-running conditions) a 28 h sleep-wake schedule, using the methods of duration estimation and duration production on target intervals of 10 and 40 s. Our findings of opposing oscillatory time courses across both epochs of sustained wakefulness that combine with increasing and, respectively, decreasing, saturating exponential change for the tasks of estimation and production are consistent with the hypothesis that a pacemaker emitting pulses at a rate controlled by the circadian oscillator and increasing with time awake determines human short-term interval timing; the duration-specificity of this pattern is interpreted as reflecting challenges to maintaining stable attention to the task that progressively increase with stimulus magnitude and thereby moderate the effects of pacemaker-rate changes on overt behavior. |
format | Online Article Text |
id | pubmed-4330698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-43306982015-03-04 Modeling circadian and sleep-homeostatic effects on short-term interval timing Späti, Jakub Aritake, Sayaka Meyer, Andrea H. Kitamura, Shingo Hida, Akiko Higuchi, Shigekazu Moriguchi, Yoshiya Mishima, Kazuo Front Integr Neurosci Neuroscience Short-term interval timing i.e., perception and action relating to durations in the seconds range, has been suggested to display time-of-day as well as wake dependent fluctuations due to circadian and sleep-homeostatic changes to the rate at which an underlying pacemaker emits pulses; pertinent human data being relatively sparse and lacking in consistency however, the phenomenon remains elusive and its mechanism poorly understood. To better characterize the putative circadian and sleep-homeostatic effects on interval timing and to assess the ability of a pacemaker-based mechanism to account for the data, we measured timing performance in eighteen young healthy male subjects across two epochs of sustained wakefulness of 38.67 h each, conducted prior to (under entrained conditions) and following (under free-running conditions) a 28 h sleep-wake schedule, using the methods of duration estimation and duration production on target intervals of 10 and 40 s. Our findings of opposing oscillatory time courses across both epochs of sustained wakefulness that combine with increasing and, respectively, decreasing, saturating exponential change for the tasks of estimation and production are consistent with the hypothesis that a pacemaker emitting pulses at a rate controlled by the circadian oscillator and increasing with time awake determines human short-term interval timing; the duration-specificity of this pattern is interpreted as reflecting challenges to maintaining stable attention to the task that progressively increase with stimulus magnitude and thereby moderate the effects of pacemaker-rate changes on overt behavior. Frontiers Media S.A. 2015-02-17 /pmc/articles/PMC4330698/ /pubmed/25741253 http://dx.doi.org/10.3389/fnint.2015.00015 Text en Copyright © 2015 Späti, Aritake, Meyer, Kitamura, Hida, Higuchi, Moriguchi and Mishima. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Späti, Jakub Aritake, Sayaka Meyer, Andrea H. Kitamura, Shingo Hida, Akiko Higuchi, Shigekazu Moriguchi, Yoshiya Mishima, Kazuo Modeling circadian and sleep-homeostatic effects on short-term interval timing |
title | Modeling circadian and sleep-homeostatic effects on short-term interval timing |
title_full | Modeling circadian and sleep-homeostatic effects on short-term interval timing |
title_fullStr | Modeling circadian and sleep-homeostatic effects on short-term interval timing |
title_full_unstemmed | Modeling circadian and sleep-homeostatic effects on short-term interval timing |
title_short | Modeling circadian and sleep-homeostatic effects on short-term interval timing |
title_sort | modeling circadian and sleep-homeostatic effects on short-term interval timing |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330698/ https://www.ncbi.nlm.nih.gov/pubmed/25741253 http://dx.doi.org/10.3389/fnint.2015.00015 |
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