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Cellular hyper-excitability caused by mutations that alter the activation process of voltage-gated sodium channels
Voltage-gated sodium channels (Na(v)) are widely expressed as macro-molecular complexes in both excitable and non-excitable tissues. In excitable tissues, the upstroke of the action potential is the result of the passage of a large and rapid influx of sodium ions through these channels. Na(V) dysfun...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330716/ https://www.ncbi.nlm.nih.gov/pubmed/25741286 http://dx.doi.org/10.3389/fphys.2015.00045 |