Abnormal cortical synaptic transmission in Ca(V)2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans

Familial hemiplegic migraine type 1 (FHM1) is caused by gain-of-function mutations in Ca(V)2.1 (P/Q-type) Ca(2+) channels. Knockin (KI) mice carrying the FHM1 R192Q missense mutation show enhanced cortical excitatory synaptic transmission at pyramidal cell synapses but unaltered cortical inhibitory...

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Detalles Bibliográficos
Autores principales: Vecchia, Dania, Tottene, Angelita, van den Maagdenberg, Arn M.J.M., Pietrobon, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330891/
https://www.ncbi.nlm.nih.gov/pubmed/25741235
http://dx.doi.org/10.3389/fncel.2015.00008

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