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Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury
Acute lung injury (ALI) occurs frequently in patients with severe traumatic brain injury (TBI) and is associated with a poor clinical outcome. Aquaporins (AQPs), particularly AQP1 and AQP4, maintain water balances between the epithelial and microvascular domains of the lung. Since pulmonary edema (P...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330958/ https://www.ncbi.nlm.nih.gov/pubmed/25705683 http://dx.doi.org/10.1155/2015/729831 |
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author | Chen, Gunng-Shinng Huang, Kuo-Feng Huang, Chien-Chu Wang, Jia-Yi |
author_facet | Chen, Gunng-Shinng Huang, Kuo-Feng Huang, Chien-Chu Wang, Jia-Yi |
author_sort | Chen, Gunng-Shinng |
collection | PubMed |
description | Acute lung injury (ALI) occurs frequently in patients with severe traumatic brain injury (TBI) and is associated with a poor clinical outcome. Aquaporins (AQPs), particularly AQP1 and AQP4, maintain water balances between the epithelial and microvascular domains of the lung. Since pulmonary edema (PE) usually occurs in the TBI-induced ALI patients, we investigated the effects of a thaliporphine derivative, TM-1, on the expression of AQPs and histological outcomes in the lung following TBI in rats. TM-1 administered (10 mg/kg, intraperitoneal injection) at 3 or 4 h after TBI significantly reduced the elevated mRNA expression and protein levels of AQP1 and AQP4 and diminished the wet/dry weight ratio, which reflects PE, in the lung at 8 and 24 h after TBI. Postinjury TM-1 administration also improved histopathological changes at 8 and 24 h after TBI. PE was accompanied with tissue pathological changes because a positive correlation between the lung injury score and the wet/dry weight ratio in the same animal was observed. Postinjury administration of TM-1 improved ALI and reduced PE at 8 and 24 h following TBI. The pulmonary-protective effect of TM-1 may be attributed to, at least in part, downregulation of AQP1 and AQP4 expression after TBI. |
format | Online Article Text |
id | pubmed-4330958 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43309582015-02-22 Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury Chen, Gunng-Shinng Huang, Kuo-Feng Huang, Chien-Chu Wang, Jia-Yi Biomed Res Int Research Article Acute lung injury (ALI) occurs frequently in patients with severe traumatic brain injury (TBI) and is associated with a poor clinical outcome. Aquaporins (AQPs), particularly AQP1 and AQP4, maintain water balances between the epithelial and microvascular domains of the lung. Since pulmonary edema (PE) usually occurs in the TBI-induced ALI patients, we investigated the effects of a thaliporphine derivative, TM-1, on the expression of AQPs and histological outcomes in the lung following TBI in rats. TM-1 administered (10 mg/kg, intraperitoneal injection) at 3 or 4 h after TBI significantly reduced the elevated mRNA expression and protein levels of AQP1 and AQP4 and diminished the wet/dry weight ratio, which reflects PE, in the lung at 8 and 24 h after TBI. Postinjury TM-1 administration also improved histopathological changes at 8 and 24 h after TBI. PE was accompanied with tissue pathological changes because a positive correlation between the lung injury score and the wet/dry weight ratio in the same animal was observed. Postinjury administration of TM-1 improved ALI and reduced PE at 8 and 24 h following TBI. The pulmonary-protective effect of TM-1 may be attributed to, at least in part, downregulation of AQP1 and AQP4 expression after TBI. Hindawi Publishing Corporation 2015 2015-02-01 /pmc/articles/PMC4330958/ /pubmed/25705683 http://dx.doi.org/10.1155/2015/729831 Text en Copyright © 2015 Gunng-Shinng Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Chen, Gunng-Shinng Huang, Kuo-Feng Huang, Chien-Chu Wang, Jia-Yi Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury |
title | Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury |
title_full | Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury |
title_fullStr | Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury |
title_full_unstemmed | Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury |
title_short | Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury |
title_sort | thaliporphine derivative improves acute lung injury after traumatic brain injury |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330958/ https://www.ncbi.nlm.nih.gov/pubmed/25705683 http://dx.doi.org/10.1155/2015/729831 |
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