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Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury

Acute lung injury (ALI) occurs frequently in patients with severe traumatic brain injury (TBI) and is associated with a poor clinical outcome. Aquaporins (AQPs), particularly AQP1 and AQP4, maintain water balances between the epithelial and microvascular domains of the lung. Since pulmonary edema (P...

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Autores principales: Chen, Gunng-Shinng, Huang, Kuo-Feng, Huang, Chien-Chu, Wang, Jia-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330958/
https://www.ncbi.nlm.nih.gov/pubmed/25705683
http://dx.doi.org/10.1155/2015/729831
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author Chen, Gunng-Shinng
Huang, Kuo-Feng
Huang, Chien-Chu
Wang, Jia-Yi
author_facet Chen, Gunng-Shinng
Huang, Kuo-Feng
Huang, Chien-Chu
Wang, Jia-Yi
author_sort Chen, Gunng-Shinng
collection PubMed
description Acute lung injury (ALI) occurs frequently in patients with severe traumatic brain injury (TBI) and is associated with a poor clinical outcome. Aquaporins (AQPs), particularly AQP1 and AQP4, maintain water balances between the epithelial and microvascular domains of the lung. Since pulmonary edema (PE) usually occurs in the TBI-induced ALI patients, we investigated the effects of a thaliporphine derivative, TM-1, on the expression of AQPs and histological outcomes in the lung following TBI in rats. TM-1 administered (10 mg/kg, intraperitoneal injection) at 3 or 4 h after TBI significantly reduced the elevated mRNA expression and protein levels of AQP1 and AQP4 and diminished the wet/dry weight ratio, which reflects PE, in the lung at 8 and 24 h after TBI. Postinjury TM-1 administration also improved histopathological changes at 8 and 24 h after TBI. PE was accompanied with tissue pathological changes because a positive correlation between the lung injury score and the wet/dry weight ratio in the same animal was observed. Postinjury administration of TM-1 improved ALI and reduced PE at 8 and 24 h following TBI. The pulmonary-protective effect of TM-1 may be attributed to, at least in part, downregulation of AQP1 and AQP4 expression after TBI.
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spelling pubmed-43309582015-02-22 Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury Chen, Gunng-Shinng Huang, Kuo-Feng Huang, Chien-Chu Wang, Jia-Yi Biomed Res Int Research Article Acute lung injury (ALI) occurs frequently in patients with severe traumatic brain injury (TBI) and is associated with a poor clinical outcome. Aquaporins (AQPs), particularly AQP1 and AQP4, maintain water balances between the epithelial and microvascular domains of the lung. Since pulmonary edema (PE) usually occurs in the TBI-induced ALI patients, we investigated the effects of a thaliporphine derivative, TM-1, on the expression of AQPs and histological outcomes in the lung following TBI in rats. TM-1 administered (10 mg/kg, intraperitoneal injection) at 3 or 4 h after TBI significantly reduced the elevated mRNA expression and protein levels of AQP1 and AQP4 and diminished the wet/dry weight ratio, which reflects PE, in the lung at 8 and 24 h after TBI. Postinjury TM-1 administration also improved histopathological changes at 8 and 24 h after TBI. PE was accompanied with tissue pathological changes because a positive correlation between the lung injury score and the wet/dry weight ratio in the same animal was observed. Postinjury administration of TM-1 improved ALI and reduced PE at 8 and 24 h following TBI. The pulmonary-protective effect of TM-1 may be attributed to, at least in part, downregulation of AQP1 and AQP4 expression after TBI. Hindawi Publishing Corporation 2015 2015-02-01 /pmc/articles/PMC4330958/ /pubmed/25705683 http://dx.doi.org/10.1155/2015/729831 Text en Copyright © 2015 Gunng-Shinng Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Gunng-Shinng
Huang, Kuo-Feng
Huang, Chien-Chu
Wang, Jia-Yi
Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury
title Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury
title_full Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury
title_fullStr Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury
title_full_unstemmed Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury
title_short Thaliporphine Derivative Improves Acute Lung Injury after Traumatic Brain Injury
title_sort thaliporphine derivative improves acute lung injury after traumatic brain injury
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330958/
https://www.ncbi.nlm.nih.gov/pubmed/25705683
http://dx.doi.org/10.1155/2015/729831
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