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Ursolic Acid Attenuates Diabetic Mesangial Cell Injury through the Up-Regulation of Autophagy via miRNA-21/PTEN/Akt/mTOR Suppression

OBJECTIVE: To investigate the effect of ursolic acid on autophagy mediated through the miRNA-21-targeted phosphoinositide 3 kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway in rat mesangial cells cultured under high glucose (HG) conditions. METHODS: Rat glomerular me...

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Detalles Bibliográficos
Autores principales:	Lu, Xinxing, Fan, Qiuling, Xu, Li, Li, Lin, Yue, Yuan, Xu, Yanyan, Su, Yan, Zhang, Dongcheng, Wang, Lining
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331365/ https://www.ncbi.nlm.nih.gov/pubmed/25689721 http://dx.doi.org/10.1371/journal.pone.0117400

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