Design and Synthesis of Novel Isoxazole Tethered Quinone-Amino Acid Hybrids

A new series of isoxazole tethered quinone-amino acid hybrids has been designed and synthesized involving 1,3-dipolar cycloaddition reaction followed by an oxidation reaction using cerium ammonium nitrate (CAN). Using this method, for the first time various isoxazole tethered quinone-phenyl alanine...

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Autores principales: Ravi Kumar, P., Behera, Manoranjan, Sambaiah, M., Kandula, Venu, Payili, Nagaraju, Jaya Shree, A., Yennam, Satyanarayana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331483/
https://www.ncbi.nlm.nih.gov/pubmed/25709839
http://dx.doi.org/10.1155/2014/721291
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author Ravi Kumar, P.
Behera, Manoranjan
Sambaiah, M.
Kandula, Venu
Payili, Nagaraju
Jaya Shree, A.
Yennam, Satyanarayana
author_facet Ravi Kumar, P.
Behera, Manoranjan
Sambaiah, M.
Kandula, Venu
Payili, Nagaraju
Jaya Shree, A.
Yennam, Satyanarayana
author_sort Ravi Kumar, P.
collection PubMed
description A new series of isoxazole tethered quinone-amino acid hybrids has been designed and synthesized involving 1,3-dipolar cycloaddition reaction followed by an oxidation reaction using cerium ammonium nitrate (CAN). Using this method, for the first time various isoxazole tethered quinone-phenyl alanine and quinone-alanine hybrids were synthesized from simple commercially available 4-bromobenzyl bromide, propargyl bromide, and 2,5-dimethoxybenzaldehyde in good yield.
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spelling pubmed-43314832015-02-23 Design and Synthesis of Novel Isoxazole Tethered Quinone-Amino Acid Hybrids Ravi Kumar, P. Behera, Manoranjan Sambaiah, M. Kandula, Venu Payili, Nagaraju Jaya Shree, A. Yennam, Satyanarayana J Amino Acids Research Article A new series of isoxazole tethered quinone-amino acid hybrids has been designed and synthesized involving 1,3-dipolar cycloaddition reaction followed by an oxidation reaction using cerium ammonium nitrate (CAN). Using this method, for the first time various isoxazole tethered quinone-phenyl alanine and quinone-alanine hybrids were synthesized from simple commercially available 4-bromobenzyl bromide, propargyl bromide, and 2,5-dimethoxybenzaldehyde in good yield. Hindawi Publishing Corporation 2014 2014-11-19 /pmc/articles/PMC4331483/ /pubmed/25709839 http://dx.doi.org/10.1155/2014/721291 Text en Copyright © 2014 P. Ravi Kumar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ravi Kumar, P.
Behera, Manoranjan
Sambaiah, M.
Kandula, Venu
Payili, Nagaraju
Jaya Shree, A.
Yennam, Satyanarayana
Design and Synthesis of Novel Isoxazole Tethered Quinone-Amino Acid Hybrids
title Design and Synthesis of Novel Isoxazole Tethered Quinone-Amino Acid Hybrids
title_full Design and Synthesis of Novel Isoxazole Tethered Quinone-Amino Acid Hybrids
title_fullStr Design and Synthesis of Novel Isoxazole Tethered Quinone-Amino Acid Hybrids
title_full_unstemmed Design and Synthesis of Novel Isoxazole Tethered Quinone-Amino Acid Hybrids
title_short Design and Synthesis of Novel Isoxazole Tethered Quinone-Amino Acid Hybrids
title_sort design and synthesis of novel isoxazole tethered quinone-amino acid hybrids
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331483/
https://www.ncbi.nlm.nih.gov/pubmed/25709839
http://dx.doi.org/10.1155/2014/721291
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