Cargando…

Transgenic and Mutation-Based Suppression of a Berberine Bridge Enzyme-Like (BBL) Gene Family Reduces Alkaloid Content in Field-Grown Tobacco

Motivation exists to develop tobacco cultivars with reduced nicotine content for the purpose of facilitating compliance with expected tobacco product regulations that could mandate the lowering of nicotine levels per se, or the reduction of carcinogenic alkaloid-derived tobacco specific nitrosamines...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lewis, Ramsey S., Lopez, Harry O., Bowen, Steve W., Andres, Karen R., Steede, William T., Dewey, Ralph E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331498/ https://www.ncbi.nlm.nih.gov/pubmed/25688975 http://dx.doi.org/10.1371/journal.pone.0117273

Ejemplares similares

Genetic and Agronomic Analysis of Tobacco Genotypes Exhibiting Reduced Nicotine Accumulation Due to Induced Mutations in Berberine Bridge Like (BBL) Genes
por: Lewis, Ramsey S., et al.
Publicado: (2020)

Modulation of benzylisoquinoline alkaloid biosynthesis by overexpression berberine bridge enzyme in Macleaya cordata
por: Huang, Peng, et al.
Publicado: (2018)

Multicomponent Therapeutics of Berberine Alkaloids
por: Luo, Jiaoyang, et al.
Publicado: (2013)

CLCNt2 Mediates Nitrate Content in Tobacco Leaf, Impacting the Production of Tobacco-Specific Nitrosamines in Cured Leaves
por: Bovet, Lucien, et al.
Publicado: (2022)

The Only African Wild Tobacco, Nicotiana africana: Alkaloid Content and the Effect of Herbivory
por: Marlin, Danica, et al.
Publicado: (2014)

Inverting the Regioselectivity of the Berberine Bridge Enzyme by Employing Customized Fluorine-Containing Substrates
por: Resch, Verena, et al.
Publicado: (2012)

The single berberine bridge enzyme homolog of Physcomitrella patens is a cellobiose oxidase
por: Toplak, Marina, et al.
Publicado: (2018)

Molecular Mechanisms of Action of Herbal Antifungal Alkaloid Berberine, in Candida albicans
por: Dhamgaye, Sanjiveeni, et al.
Publicado: (2014)

De novo biosynthesis of berberine and halogenated benzylisoquinoline alkaloids in Saccharomyces cerevisiae
por: Han, Jianing, et al.
Publicado: (2023)

Constitutive activation of nitrate reductase in tobacco alters flowering time and plant biomass
por: Lu, Jianli, et al.
Publicado: (2021)

BBL Mortality in South Florida: An Update From Ground Zero
por: Garcia, Onelio, et al.
Publicado: (2022)

Catalytic and Structural Role of a Conserved Active Site Histidine in Berberine Bridge Enzyme
por: Wallner, Silvia, et al.
Publicado: (2012)

Expression of a constitutively active nitrate reductase variant in tobacco reduces tobacco‐specific nitrosamine accumulation in cured leaves and cigarette smoke
por: Lu, Jianli, et al.
Publicado: (2016)

Environmental impact of switching from the synthetic glucocorticoid prednisolone to the natural alkaloid berberine
por: Allijn, Iris E., et al.
Publicado: (2018)

Combating Neurodegenerative Diseases with the Plant Alkaloid Berberine: Molecular Mechanisms and Therapeutic Potential
por: Fan, Dahua, et al.
Publicado: (2019)

A Natural Isoquinoline Alkaloid With Antitumor Activity: Studies of the Biological Activities of Berberine
por: Liu, Da, et al.
Publicado: (2019)

C(60) Fullerene as an Effective Nanoplatform of Alkaloid Berberine Delivery into Leukemic Cells
por: Grebinyk, Anna, et al.
Publicado: (2019)

Expatiating the Pharmacological and Nanotechnological Aspects of the Alkaloidal Drug Berberine: Current and Future Trends
por: Behl, Tapan, et al.
Publicado: (2022)

Structure of a Berberine Bridge Enzyme-Like Enzyme with an Active Site Specific to the Plant Family Brassicaceae
por: Daniel, Bastian, et al.
Publicado: (2016)

Multimeric forms of 4-1BBL as stimulators of T cells for adoptive immunotherapy
por: Kornbluth, Richard S, et al.
Publicado: (2014)

Recombinant salmonella-based 4-1BBL vaccine enhances T cell immunity and inhibits the development of colorectal cancer in rats: in vivo effects of vaccine containing 4-1BBL
por: Ye, Jianxin, et al.
Publicado: (2013)

Topping and grafting affect the alkaloid content and gene expression patterns of tobacco ( Nicotiana tabacum L.)
por: Zhang, Mengyue, et al.
Publicado: (2023)

Effects of Overproduction of Rubisco Activase on Rubisco Content in Transgenic Rice Grown at Different N Levels
por: Suganami, Mao, et al.
Publicado: (2020)

The Cultivation of Chelidonium majus L. Increased the Total Alkaloid Content and Cytotoxic Activity Compared with Those of Wild-Grown Plants
por: Krizhanovska, Valerija, et al.
Publicado: (2021)

Therapeutic Effect of Berberine on Huntington’s Disease Transgenic Mouse Model
por: Jiang, Wenxiao, et al.
Publicado: (2015)

Update on the Benefits and Mechanisms of Action of the Bioactive Vegetal Alkaloid Berberine on Lipid Metabolism and Homeostasis
por: Wang, Yanwen, et al.
Publicado: (2018)

The benzylisoquinoline alkaloids, berberine and coptisine, act against camptothecin-resistant topoisomerase I mutants
por: Inoue, Naomi, et al.
Publicado: (2021)

Alkaloids of Dicranostigma franchetianum (Papaveraceae) and Berberine Derivatives as a New Class of Antimycobacterial Agents
por: Wijaya, Viriyanata, et al.
Publicado: (2022)

Current perspectives of SA-4-1BBL in immune modulation during cancer
por: Zhou, Shu-Ni, et al.
Publicado: (2018)

Draft genome sequence of the moderately halophilic bacterium Halobacillus sp. BBL2006
por: Treves, David S., et al.
Publicado: (2018)

Engineered soluble, trimerized 4-1BBL variants as potent immunomodulatory agents
por: Battin, Claire, et al.
Publicado: (2023)

Overexpressing the H‐protein of the glycine cleavage system increases biomass yield in glasshouse and field‐grown transgenic tobacco plants
por: López‐Calcagno, Patricia E., et al.
Publicado: (2018)

Selective repression of RET proto-oncogene in medullary thyroid carcinoma by a natural alkaloid berberine
por: Kumarasamy, Vishnu Muthuraj, et al.
Publicado: (2015)

Exposure to the natural alkaloid Berberine affects cardiovascular system morphogenesis and functionality during zebrafish development
por: Martini, Davide, et al.
Publicado: (2020)

Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis
por: Yuan, Chuang, et al.
Publicado: (2021)

Inhibitory Role of Berberine, an Isoquinoline Alkaloid, on NLRP3 Inflammasome Activation for the Treatment of Inflammatory Diseases
por: Sarbadhikary, Paromita, et al.
Publicado: (2021)

The Change of Immunoactivity of Dendritic Cells Induced by Mouse 4-1BBL Recombinant Adenovirus
por: Youlin, Kuang, et al.
Publicado: (2010)

Combination Immunotherapy with 4-1BBL and CTLA-4 Blockade for the Treatment of Prostate Cancer
por: Youlin, Kuang, et al.
Publicado: (2012)

Effects of the Temperature and Salt Concentration on the Structural Characteristics of the Protein (PDB Code 1BBL)
por: Shao, Dongqing, et al.
Publicado: (2022)

Unraveling Biohydrogen Production and Sugar Utilization Systems in the Electricigen Shewanella marisflavi BBL25
por: Kim, Sang Hyun, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_4896qr6e8phe6h0clvcv4ldqk9