Directed Evolution of a Yeast-Displayed HIV-1 SOSIP gp140 Spike Protein toward Improved Expression and Affinity for Conformational Antibodies

Design of an envelope-based immunogen capable of inducing a broadly neutralizing antibody response is thought to be key to the development of a protective HIV-1 vaccine. However, the broad diversity of viral variants and a limited ability to produce native envelope have hampered such design efforts....

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Detalles Bibliográficos
Autores principales: Grimm, Sebastian K., Battles, Michael B., Ackerman, Margaret E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331506/
https://www.ncbi.nlm.nih.gov/pubmed/25688555
http://dx.doi.org/10.1371/journal.pone.0117227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331506/
https://www.ncbi.nlm.nih.gov/pubmed/25688555
http://dx.doi.org/10.1371/journal.pone.0117227

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