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Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress

Reduced signalling through the insulin/insulin-like growth factor-1 signalling (IIS) pathway is a highly conserved lifespan determinant in model organisms. The precise mechanism underlying the effects of the IIS on lifespan and health is currently unclear, although cellular stress resistance may be...

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Detalles Bibliográficos
Autores principales:	Page, Melissa M, Sinclair, Amy, Robb, Ellen L, Stuart, Jeffrey A, Withers, Dominic J, Selman, Colin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Short Takes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331740/ https://www.ncbi.nlm.nih.gov/pubmed/25059507 http://dx.doi.org/10.1111/acel.12255

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