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Human stem cell aging: do mitochondrial DNA mutations have a causal role?

A decline in the replicative and regenerative capacity of adult stem cell populations is a major contributor to the aging process. Mitochondrial DNA (mtDNA) mutations clonally expand with age in human stem cell compartments including the colon, small intestine, and stomach, and result in respiratory...

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Detalles Bibliográficos
Autores principales:	Baines, Holly L, Turnbull, Douglass M, Greaves, Laura C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331785/ https://www.ncbi.nlm.nih.gov/pubmed/24382254 http://dx.doi.org/10.1111/acel.12199

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