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Negative feedback buffers effects of regulatory variants

Mechanisms conferring robustness against regulatory variants have been controversial. Previous studies suggested widespread buffering of RNA misexpression on protein levels during translation. We do not find evidence that translational buffering is common. Instead, we find extensive buffering at the...

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Detalles Bibliográficos
Autores principales:	Bader, Daniel M, Wilkening, Stefan, Lin, Gen, Tekkedil, Manu M, Dietrich, Kim, Steinmetz, Lars M, Gagneur, Julien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332157/ https://www.ncbi.nlm.nih.gov/pubmed/25634765 http://dx.doi.org/10.15252/msb.20145844

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