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Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models

Patients with schizophrenia are at an increased risk for the development of depression. Overlap in the symptoms and genetic risk factors between the two disorders suggests a common etiological mechanism may underlie the presentation of comorbid depression in schizophrenia. Understanding these shared...

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Autores principales: Samsom, James N., Wong, Albert H. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332163/
https://www.ncbi.nlm.nih.gov/pubmed/25762938
http://dx.doi.org/10.3389/fpsyt.2015.00013
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author Samsom, James N.
Wong, Albert H. C.
author_facet Samsom, James N.
Wong, Albert H. C.
author_sort Samsom, James N.
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description Patients with schizophrenia are at an increased risk for the development of depression. Overlap in the symptoms and genetic risk factors between the two disorders suggests a common etiological mechanism may underlie the presentation of comorbid depression in schizophrenia. Understanding these shared mechanisms will be important in informing the development of new treatments. Rodent models are powerful tools for understanding gene function as it relates to behavior. Examining rodent models relevant to both schizophrenia and depression reveals a number of common mechanisms. Current models which demonstrate endophenotypes of both schizophrenia and depression are reviewed here, including models of CUB and SUSHI multiple domains 1, PDZ and LIM domain 5, glutamate Delta 1 receptor, diabetic db/db mice, neuropeptide Y, disrupted in schizophrenia 1, and its interacting partners, reelin, maternal immune activation, and social isolation. Neurotransmission, brain connectivity, the immune system, the environment, and metabolism emerge as potential common mechanisms linking these models and potentially explaining comorbid depression in schizophrenia.
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spelling pubmed-43321632015-03-11 Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models Samsom, James N. Wong, Albert H. C. Front Psychiatry Psychiatry Patients with schizophrenia are at an increased risk for the development of depression. Overlap in the symptoms and genetic risk factors between the two disorders suggests a common etiological mechanism may underlie the presentation of comorbid depression in schizophrenia. Understanding these shared mechanisms will be important in informing the development of new treatments. Rodent models are powerful tools for understanding gene function as it relates to behavior. Examining rodent models relevant to both schizophrenia and depression reveals a number of common mechanisms. Current models which demonstrate endophenotypes of both schizophrenia and depression are reviewed here, including models of CUB and SUSHI multiple domains 1, PDZ and LIM domain 5, glutamate Delta 1 receptor, diabetic db/db mice, neuropeptide Y, disrupted in schizophrenia 1, and its interacting partners, reelin, maternal immune activation, and social isolation. Neurotransmission, brain connectivity, the immune system, the environment, and metabolism emerge as potential common mechanisms linking these models and potentially explaining comorbid depression in schizophrenia. Frontiers Media S.A. 2015-02-18 /pmc/articles/PMC4332163/ /pubmed/25762938 http://dx.doi.org/10.3389/fpsyt.2015.00013 Text en Copyright © 2015 Samsom and Wong. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Samsom, James N.
Wong, Albert H. C.
Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models
title Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models
title_full Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models
title_fullStr Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models
title_full_unstemmed Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models
title_short Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models
title_sort schizophrenia and depression co-morbidity: what we have learned from animal models
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332163/
https://www.ncbi.nlm.nih.gov/pubmed/25762938
http://dx.doi.org/10.3389/fpsyt.2015.00013
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