Toxoplasma gondii Exposure and the Risk of Schizophrenia

BACKGROUND: Schizophrenia is a major psychiatric disorder with a deeply destructive pathophysiology. There are evidences to indicate that infectious agents such as Toxoplasma gondii may play some roles in etiology of the disorder. OBJECTIVES: The current study aimed to determine the association betw...

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Detalles Bibliográficos
Autores principales: Khademvatan, Shahram, Saki, Jasem, Khajeddin, Niloufar, Izadi-Mazidi, Maryam, Beladi, Reza, Shafiee, Behnaz, Salehi, Zahra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332237/
https://www.ncbi.nlm.nih.gov/pubmed/25774275
http://dx.doi.org/10.5812/jjm.12776
Descripción
Sumario:BACKGROUND: Schizophrenia is a major psychiatric disorder with a deeply destructive pathophysiology. There are evidences to indicate that infectious agents such as Toxoplasma gondii may play some roles in etiology of the disorder. OBJECTIVES: The current study aimed to determine the association between T. gondii exposure and the risk of schizophrenia. MATERIALS AND METHODS: T. gondii IgG antibodies of 100 patients with schizophrenia as well as 200 healthy volunteers were assessed. The subjects also completed demographic questionnaires. Data was analyzed using the chi-square and Fisher exact tests. RESULTS: The analyses confirmed the significant differences between healthy women and ones with schizophrenia (P = 0.001) as well as between males and females with schizophrenia (P = 0.009) in IgG positivity. CONCLUSIONS: The present study supported the contamination with T. gondii as a risk factor for schizophrenia just in women.

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