The clue of a possible etiology about spontaneous regression of hepatocellular carcinoma: a perspective on pathology

Spontaneous regression of hepatocellular carcinoma (HCC) is a rare event. However, only a few of the causes of cases of HCC spontaneous regression are clear. More cases are ambiguous. We report on a patient who had a spontaneous regression of HCC as detected by histological and immunohistochemical e...

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Detalles Bibliográficos
Autores principales: Wang, Zhuo, Ke, Zun-Fu, Lu, Xiao-Fang, Luo, Can-Jiao, Liu, Yong-Dong, Lin, Zhong-Wei, Wang, Lian-Tang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332258/
https://www.ncbi.nlm.nih.gov/pubmed/25709471
http://dx.doi.org/10.2147/OTT.S79102
Descripción
Sumario:Spontaneous regression of hepatocellular carcinoma (HCC) is a rare event. However, only a few of the causes of cases of HCC spontaneous regression are clear. More cases are ambiguous. We report on a patient who had a spontaneous regression of HCC as detected by histological and immunohistochemical exam, and compared this case to 20 cases of non-specific HCC. In our case, we found that the odd phenomenon is that CD163(+) macrophages are overactivated in surviving HCC, which is spontaneously regressing. Concomitantly, we cannot find a similar phenomenon in peritumoral liver tissue or non-specific HCC. According to our microscopical morphology and immunohistochemical study, we considered that a clue of a possible etiology about HCC spontaneous regression is that CD163(+) macrophages are overactivated.

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