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Autophagy in Thyroid Cancer: Present Knowledge and Future Perspectives

Thyroid cancer is the most common endocrine malignancy. Despite having a good prognosis in the majority of cases, when the tumor is dedifferentiated it does no longer respond to conventional treatment with radioactive iodine, the prognosis worsens significantly. Treatment options for advanced, dedif...

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Autores principales: Netea-Maier, Romana T., Klück, Viola, Plantinga, Theo S., Smit, Johannes W. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332359/
https://www.ncbi.nlm.nih.gov/pubmed/25741318
http://dx.doi.org/10.3389/fendo.2015.00022
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author Netea-Maier, Romana T.
Klück, Viola
Plantinga, Theo S.
Smit, Johannes W. A.
author_facet Netea-Maier, Romana T.
Klück, Viola
Plantinga, Theo S.
Smit, Johannes W. A.
author_sort Netea-Maier, Romana T.
collection PubMed
description Thyroid cancer is the most common endocrine malignancy. Despite having a good prognosis in the majority of cases, when the tumor is dedifferentiated it does no longer respond to conventional treatment with radioactive iodine, the prognosis worsens significantly. Treatment options for advanced, dedifferentiated disease are limited and do not cure the disease. Autophagy, a process of self-digestion in which damaged molecules or organelles are degraded and recycled, has emerged as an important player in the pathogenesis of different diseases, including cancer. The role of autophagy in thyroid cancer pathogenesis is not yet elucidated. However, the available data indicate that autophagy is involved in several steps of thyroid tumor initiation and progression as well as in therapy resistance and therefore could be exploited for therapeutic applications. The present review summarizes the most recent data on the role of autophagy in the pathogenesis of thyroid cancer and we will provide a perspective on how this process can be targeted for potential therapeutic approaches and could be further explored in the context of multimodality treatment in cancer and personalized medicine.
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spelling pubmed-43323592015-03-04 Autophagy in Thyroid Cancer: Present Knowledge and Future Perspectives Netea-Maier, Romana T. Klück, Viola Plantinga, Theo S. Smit, Johannes W. A. Front Endocrinol (Lausanne) Endocrinology Thyroid cancer is the most common endocrine malignancy. Despite having a good prognosis in the majority of cases, when the tumor is dedifferentiated it does no longer respond to conventional treatment with radioactive iodine, the prognosis worsens significantly. Treatment options for advanced, dedifferentiated disease are limited and do not cure the disease. Autophagy, a process of self-digestion in which damaged molecules or organelles are degraded and recycled, has emerged as an important player in the pathogenesis of different diseases, including cancer. The role of autophagy in thyroid cancer pathogenesis is not yet elucidated. However, the available data indicate that autophagy is involved in several steps of thyroid tumor initiation and progression as well as in therapy resistance and therefore could be exploited for therapeutic applications. The present review summarizes the most recent data on the role of autophagy in the pathogenesis of thyroid cancer and we will provide a perspective on how this process can be targeted for potential therapeutic approaches and could be further explored in the context of multimodality treatment in cancer and personalized medicine. Frontiers Media S.A. 2015-02-18 /pmc/articles/PMC4332359/ /pubmed/25741318 http://dx.doi.org/10.3389/fendo.2015.00022 Text en Copyright © 2015 Netea-Maier, Klück, Plantinga and Smit. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Netea-Maier, Romana T.
Klück, Viola
Plantinga, Theo S.
Smit, Johannes W. A.
Autophagy in Thyroid Cancer: Present Knowledge and Future Perspectives
title Autophagy in Thyroid Cancer: Present Knowledge and Future Perspectives
title_full Autophagy in Thyroid Cancer: Present Knowledge and Future Perspectives
title_fullStr Autophagy in Thyroid Cancer: Present Knowledge and Future Perspectives
title_full_unstemmed Autophagy in Thyroid Cancer: Present Knowledge and Future Perspectives
title_short Autophagy in Thyroid Cancer: Present Knowledge and Future Perspectives
title_sort autophagy in thyroid cancer: present knowledge and future perspectives
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332359/
https://www.ncbi.nlm.nih.gov/pubmed/25741318
http://dx.doi.org/10.3389/fendo.2015.00022
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