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Functional and dysfunctional conformers of human neuroserpin characterized by optical spectroscopies and Molecular Dynamics

Neuroserpin (NS) is a serine protease inhibitor (SERPIN) involved in different neurological pathologies, including the Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB), related to the aberrant polymerization of NS mutants. Here we present an in vitro and in silico characterization o...

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Detalles Bibliográficos
Autores principales:	Noto, Rosina, Santangelo, Maria Grazia, Levantino, Matteo, Cupane, Antonio, Mangione, Maria Rosalia, Parisi, Daniele, Ricagno, Stefano, Bolognesi, Martino, Manno, Mauro, Martorana, Vincenzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Pub. Co 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332418/ https://www.ncbi.nlm.nih.gov/pubmed/25450507 http://dx.doi.org/10.1016/j.bbapap.2014.10.002

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