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Role of adiponectin and free fatty acids on the association between abdominal visceral fat and insulin resistance
BACKGROUND: Experimental studies have shown that high free fatty acid (FFA) and low adiponectin (ADIPO) levels are involved in the mechanisms by which adiposity promotes insulin resistance (IR). However, no previous clinical studies have simultaneously analysed the relative contribution of FFA and A...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332423/ https://www.ncbi.nlm.nih.gov/pubmed/25849597 http://dx.doi.org/10.1186/s12933-015-0184-5 |
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author | Medina-Urrutia, Aida Posadas-Romero, Carlos Posadas-Sánchez, Rosalinda Jorge-Galarza, Esteban Villarreal-Molina, Teresa González-Salazar, María del Carmen Cardoso-Saldaña, Guillermo Vargas-Alarcón, Gilberto Torres-Tamayo, Margarita Juárez-Rojas, Juan Gabriel |
author_facet | Medina-Urrutia, Aida Posadas-Romero, Carlos Posadas-Sánchez, Rosalinda Jorge-Galarza, Esteban Villarreal-Molina, Teresa González-Salazar, María del Carmen Cardoso-Saldaña, Guillermo Vargas-Alarcón, Gilberto Torres-Tamayo, Margarita Juárez-Rojas, Juan Gabriel |
author_sort | Medina-Urrutia, Aida |
collection | PubMed |
description | BACKGROUND: Experimental studies have shown that high free fatty acid (FFA) and low adiponectin (ADIPO) levels are involved in the mechanisms by which adiposity promotes insulin resistance (IR). However, no previous clinical studies have simultaneously analysed the relative contribution of FFA and ADIPO levels on the relation of abdominal visceral fat (AVF) with insulin resistance. OBJECTIVE: To analyse the contribution of low ADIPO (adiponectin < =p25th: 8.67 μg/mL in women and 5.30 μg/mL in men), and high FFAs (FFAs > =p75th: 0.745 mEq/L in women and 0.60 mEq/L in men) to the association of high AVF (AVF > =p75th: 127 cm(2) in women; 152.7 cm(2) in men) with insulin resistance (HOMA-IR > =75th: 3.58 in women and 3.12 in men), in non-diabetic subjects. MATERIAL AND METHODS: A cross-sectional analysis was performed including 1217 control participants of the Genetics of Atherosclerotic Disease study (GEA). Clinical, tomographic and biochemical parameters were measured in all participants. Logistic regression models were used to assess the association of high AVF with IR stratifying according to gender, and to normal or low ADIPO and normal or high FFA serum levels. RESULTS: In comparison to referent group, in men low ADIPO unlike high FFA increased the risk of IR. Females with normal AVF and low ADIPO, or high AVF and normal ADIPO had aprox 3 folds risk of IR (OR [IC95%]: 3.7 [2.1-6.6], p < 0.001, and 3.4 [2.0-5.7], p < 0.001; respectively). The risk increased to 7.6 [4.2-13.8], p < 0.001 when high AVF and low ADIPO were present. Irrespective of AVF, the effect of low ADIPO on IR was higher than that seen for high FFA. Besides, our results suggest an additive effect of high AVF, high FFA and low ADIPO on the IR prevalence. CONCLUSIONS: The present study provides novel and important information about the combined effect of high AVF and low ADIPO on the risk of IR. Furthermore, our data suggest that the effect of low adiponectin levels on the high AVF-IR association is stronger than that observed for high FFA, suggesting that adiponectin could be used as biomarker to identify subjects at high risk for T2DM and CAD. |
format | Online Article Text |
id | pubmed-4332423 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43324232015-02-19 Role of adiponectin and free fatty acids on the association between abdominal visceral fat and insulin resistance Medina-Urrutia, Aida Posadas-Romero, Carlos Posadas-Sánchez, Rosalinda Jorge-Galarza, Esteban Villarreal-Molina, Teresa González-Salazar, María del Carmen Cardoso-Saldaña, Guillermo Vargas-Alarcón, Gilberto Torres-Tamayo, Margarita Juárez-Rojas, Juan Gabriel Cardiovasc Diabetol Original Investigation BACKGROUND: Experimental studies have shown that high free fatty acid (FFA) and low adiponectin (ADIPO) levels are involved in the mechanisms by which adiposity promotes insulin resistance (IR). However, no previous clinical studies have simultaneously analysed the relative contribution of FFA and ADIPO levels on the relation of abdominal visceral fat (AVF) with insulin resistance. OBJECTIVE: To analyse the contribution of low ADIPO (adiponectin < =p25th: 8.67 μg/mL in women and 5.30 μg/mL in men), and high FFAs (FFAs > =p75th: 0.745 mEq/L in women and 0.60 mEq/L in men) to the association of high AVF (AVF > =p75th: 127 cm(2) in women; 152.7 cm(2) in men) with insulin resistance (HOMA-IR > =75th: 3.58 in women and 3.12 in men), in non-diabetic subjects. MATERIAL AND METHODS: A cross-sectional analysis was performed including 1217 control participants of the Genetics of Atherosclerotic Disease study (GEA). Clinical, tomographic and biochemical parameters were measured in all participants. Logistic regression models were used to assess the association of high AVF with IR stratifying according to gender, and to normal or low ADIPO and normal or high FFA serum levels. RESULTS: In comparison to referent group, in men low ADIPO unlike high FFA increased the risk of IR. Females with normal AVF and low ADIPO, or high AVF and normal ADIPO had aprox 3 folds risk of IR (OR [IC95%]: 3.7 [2.1-6.6], p < 0.001, and 3.4 [2.0-5.7], p < 0.001; respectively). The risk increased to 7.6 [4.2-13.8], p < 0.001 when high AVF and low ADIPO were present. Irrespective of AVF, the effect of low ADIPO on IR was higher than that seen for high FFA. Besides, our results suggest an additive effect of high AVF, high FFA and low ADIPO on the IR prevalence. CONCLUSIONS: The present study provides novel and important information about the combined effect of high AVF and low ADIPO on the risk of IR. Furthermore, our data suggest that the effect of low adiponectin levels on the high AVF-IR association is stronger than that observed for high FFA, suggesting that adiponectin could be used as biomarker to identify subjects at high risk for T2DM and CAD. BioMed Central 2015-02-10 /pmc/articles/PMC4332423/ /pubmed/25849597 http://dx.doi.org/10.1186/s12933-015-0184-5 Text en © Medina-Urrutia et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Original Investigation Medina-Urrutia, Aida Posadas-Romero, Carlos Posadas-Sánchez, Rosalinda Jorge-Galarza, Esteban Villarreal-Molina, Teresa González-Salazar, María del Carmen Cardoso-Saldaña, Guillermo Vargas-Alarcón, Gilberto Torres-Tamayo, Margarita Juárez-Rojas, Juan Gabriel Role of adiponectin and free fatty acids on the association between abdominal visceral fat and insulin resistance |
title | Role of adiponectin and free fatty acids on the association between abdominal visceral fat and insulin resistance |
title_full | Role of adiponectin and free fatty acids on the association between abdominal visceral fat and insulin resistance |
title_fullStr | Role of adiponectin and free fatty acids on the association between abdominal visceral fat and insulin resistance |
title_full_unstemmed | Role of adiponectin and free fatty acids on the association between abdominal visceral fat and insulin resistance |
title_short | Role of adiponectin and free fatty acids on the association between abdominal visceral fat and insulin resistance |
title_sort | role of adiponectin and free fatty acids on the association between abdominal visceral fat and insulin resistance |
topic | Original Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332423/ https://www.ncbi.nlm.nih.gov/pubmed/25849597 http://dx.doi.org/10.1186/s12933-015-0184-5 |
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