The N-Terminal Residues 43 to 60 Form the Interface for Dopamine Mediated α-Synuclein Dimerisation

α-synuclein (α-syn) is a major component of the intracellular inclusions called Lewy bodies, which are a key pathological feature in the brains of Parkinson’s disease patients. The neurotransmitter dopamine (DA) inhibits the fibrillisation of α-syn into amyloid, and promotes α-syn aggregation into S...

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Detalles Bibliográficos
Autores principales: Leong, Su Ling, Hinds, Mark G., Connor, Andrea R., Smith, David P., Illes-Toth, Eva, Pham, Chi L. L., Barnham, Kevin J., Cappai, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332483/
https://www.ncbi.nlm.nih.gov/pubmed/25679387
http://dx.doi.org/10.1371/journal.pone.0116497

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