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Bactobolin A Binds to a Site on the 70S Ribosome Distinct from Previously Seen Antibiotics
The ribosome is the target of a large number of antibiotics. Here, we report a 3.4-Å-resolution crystal structure of bactobolin A bound to 70S ribosome–tRNA complex. The antibiotic binds at a previously unseen site in the 50S subunit and displaces tRNA bound at the P-site. It thus likely has a simil...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332689/ https://www.ncbi.nlm.nih.gov/pubmed/25562208 http://dx.doi.org/10.1016/j.jmb.2014.12.018 |