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Flexible Stoichiometry and Asymmetry of the PIDDosome Core Complex by Heteronuclear NMR Spectroscopy and Mass Spectrometry

Homotypic death domain (DD)–DD interactions are important in the assembly of oligomeric signaling complexes such as the PIDDosome that acts as a platform for activation of caspase-2-dependent apoptotic signaling. The structure of the PIDDosome core complex exhibits an asymmetric three-layered arrang...

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Detalles Bibliográficos
Autores principales:	Nematollahi, Lily A., Garza-Garcia, Acely, Bechara, Chérine, Esposito, Diego, Morgner, Nina, Robinson, Carol V., Driscoll, Paul C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Featured Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332690/ https://www.ncbi.nlm.nih.gov/pubmed/25528640 http://dx.doi.org/10.1016/j.jmb.2014.11.021

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