Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis

INTRODUCTION: Transducer of Cdc42-dependent actin assembly-1 (Toca-1) recruits actin regulatory proteins to invadopodia, and promotes breast tumor metastasis. Since metastatic breast tumors frequently harbor mutations in the tumor suppressor p53, we tested whether p53 regulates Toca-1 expression. ME...

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Detalles Bibliográficos
Autores principales: Chander, Harish, Brien, Colin D, Truesdell, Peter, Watt, Kathleen, Meens, Jalna, Schick, Colleen, Germain, Doris, Craig, Andrew WB
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332744/
https://www.ncbi.nlm.nih.gov/pubmed/25547174
http://dx.doi.org/10.1186/s13058-014-0503-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332744/
https://www.ncbi.nlm.nih.gov/pubmed/25547174
http://dx.doi.org/10.1186/s13058-014-0503-x

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