Cargando…

Plant Virus Particles Carrying Tumour Antigen Activate TLR7 and Induce High Levels of Protective Antibody

Induction of potent antibody is the goal of many vaccines targeted against infections or cancer. Modern vaccine designs that use virus-like particles (VLP) have shown efficacy for prophylactic vaccination against virus-associated cancer in the clinic. Here we used plant viral particles (PVP), which...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jobsri, Jantipa, Allen, Alex, Rajagopal, Deepa, Shipton, Michael, Kanyuka, Kostya, Lomonossoff, George P., Ottensmeier, Christian, Diebold, Sandra S., Stevenson, Freda K., Savelyeva, Natalia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332868/ https://www.ncbi.nlm.nih.gov/pubmed/25692288 http://dx.doi.org/10.1371/journal.pone.0118096

Ejemplares similares

A plant-expressed conjugate vaccine breaks CD4(+) tolerance and induces potent immunity against metastatic Her2(+) breast cancer
por: Chotprakaikiat, Warayut, et al.
Publicado: (2016)

HNSCC: Tumour Antigens and Their Targeting by Immunotherapy
por: von Witzleben, Adrian, et al.
Publicado: (2020)

Linear doggybone DNA vaccine induces similar immunological responses to conventional plasmid DNA independently of immune recognition by TLR9 in a pre-clinical model
por: Allen, Alex, et al.
Publicado: (2018)

Dissecting the Molecular Interactions between Wheat and the Fungal Pathogen Zymoseptoria tritici
por: Kettles, Graeme J., et al.
Publicado: (2016)

Cell surface immune receptors: the guardians of the plant’s extracellular spaces
por: Kanyuka, Kostya, et al.
Publicado: (2019)

Vaccination Expands Antigen-Specific CD4(+) Memory T Cells and Mobilizes Bystander Central Memory T Cells
por: Li Causi, Eleonora, et al.
Publicado: (2015)

Virus induced gene silencing (VIGS) for functional analysis of wheat genes involved in Zymoseptoria tritici susceptibility and resistance
por: Lee, Wing-Sham, et al.
Publicado: (2015)

Study of Virus-Like Particles in Male Mice Carrying Mammary Tumour Agent
por: Chopra, H. C.
Publicado: (1965)

Circulating Hepatitis B Surface Antigen Particles Carry Hepatocellular microRNAs
por: Novellino, Luisa, et al.
Publicado: (2012)

Force carrying particles
Publicado: (1993)

Expression of KK-LC-1, a cancer/testis antigen, at non-tumour sites of the stomach carrying a tumour
por: Fukuyama, Takashi, et al.
Publicado: (2018)

Antigen Delivery Systems III: Use of Recombinant Plant Viruses
por: Lomonossoff, George P.
Publicado: (2005)

Apoplastic recognition of multiple candidate effectors from the wheat pathogen Zymoseptoria tritici in the nonhost plant Nicotiana benthamiana
por: Kettles, Graeme J., et al.
Publicado: (2016)

Efficient CRISPR/Cas-Mediated Targeted Mutagenesis in Spring and Winter Wheat Varieties
por: Hahn, Florian, et al.
Publicado: (2021)

Development of Plant-Based Vaccines for Prevention of Avian Influenza and Newcastle Disease in Poultry
por: Nurzijah, Ika, et al.
Publicado: (2022)

Induction of distinct plant cell death programs by secreted proteins from the wheat pathogen Zymoseptoria tritici
por: Welch, Thomas, et al.
Publicado: (2022)

A large bioassay identifies Stb resistance genes that provide broad resistance against Septoria tritici blotch disease in the UK
por: Tidd, Henry, et al.
Publicado: (2023)

Exploring the diversity of promoter and 5′UTR sequences in ancestral, historic and modern wheat
por: Hammond‐Kosack, Michael C.U., et al.
Publicado: (2021)

TMV Particles: The Journey From Fundamental Studies to Bionanotechnology Applications
por: Lomonossoff, George P., et al.
Publicado: (2018)

RNAi as an emerging approach to control Fusarium head blight disease and mycotoxin contamination in cereals
por: Machado, Ana Karla, et al.
Publicado: (2017)

TLR Signaling and Tumour-Associated Macrophages
por: Colegio, Oscar R., et al.
Publicado: (2011)

PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy
por: Koerner, Julia, et al.
Publicado: (2021)

Virus-Like Particles of Chimeric Recombinant Porcine Circovirus Type 2 as Antigen Vehicle Carrying Foreign Epitopes
por: Zhang, Huawei, et al.
Publicado: (2014)

Characterization of an antimicrobial and phytotoxic ribonuclease secreted by the fungal wheat pathogen Zymoseptoria tritici
por: Kettles, Graeme J., et al.
Publicado: (2017)

GCN2-dependent phosphorylation of eukaryotic translation initiation factor-2α in Arabidopsis
por: Zhang, Yuhua, et al.
Publicado: (2008)

Transcriptome Analysis of Arabidopsis GCR1 Mutant Reveals Its Roles in Stress, Hormones, Secondary Metabolism and Phosphate Starvation
por: Chakraborty, Navjyoti, et al.
Publicado: (2015)

Sequence diversification in recessive alleles of two host factor genes suggests adaptive selection for bymovirus resistance in cultivated barley from East Asia
por: Yang, Ping, et al.
Publicado: (2016)

The vesicular trafficking system component MIN7 is required for minimizing Fusarium graminearum infection
por: Machado Wood, Ana K, et al.
Publicado: (2021)

Delivering Two Tumour Antigens Survivin and Mucin-1 on Virus-Like Particles Enhances Anti-Tumour Immune Responses
por: Campbell, Katrin, et al.
Publicado: (2021)

The Generation of Turnip Crinkle Virus-Like Particles in Plants by the Transient Expression of Wild-Type and Modified Forms of Its Coat Protein
por: Saunders, Keith, et al.
Publicado: (2015)

The effects of Ostertagia occidentalis somatic antigens on ovine TLR2 and TLR4 expression
por: BORJI, Hassan, et al.
Publicado: (2015)

Amino acids at the exposed C-terminus of the S coat protein of cowpea mosaic virus play different roles in particle formation and viral systemic movement
por: Meshcheriakova, Yulia, et al.
Publicado: (2019)

Long-term evolution of antigen repertoires among carried meningococci
por: Buckee, Caroline O., et al.
Publicado: (2010)

DArT markers: diversity analyses, genomes comparison, mapping and integration with SSR markers in Triticum monococcum
por: Jing, Hai-Chun, et al.
Publicado: (2009)

GCR1 and GPA1 coupling regulates nitrate, cell wall, immunity and light responses in Arabidopsis
por: Chakraborty, Navjyoti, et al.
Publicado: (2019)

Role of TLR3 in the immunogenicity of replicon plasmid-based vaccines
por: Diebold, Sandra S., et al.
Publicado: (2008)

Cytokine Effect of TLR3, TLR4, and TLR7 Agonists Alone or Associated with Leishmania infantum Antigen on Blood from Dogs
por: Martínez-Orellana, Pamela, et al.
Publicado: (2018)

An Expanded Self-Antigen Peptidome Is Carried by the Human Lymph As Compared to the Plasma
por: Clement, Cristina C., et al.
Publicado: (2010)

Treatment of tumour tissue with radio‐frequency hyperthermia (using antibody‐carrying nanoparticles)
por: Didarian, Reza, et al.
Publicado: (2021)

Anaphylactic tests for tumour antigen in transplantable animal tumours.
por: Dale, M. M.
Publicado: (1966)

Cannot write session to /tmp/vufind_sessions/sess_eqmmioocrss52uk1jm8eptj1b6