Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment

BACKGROUND: LAG-3 is a potent negative regulator of the immune response but its impact in HIV infection in poorly understood. Unlike exhaustion markers such as PD-1, Tim-3, 2B4 and CD160, LAG-3 is poorly expressed on bulk and antigen-specific T cells during chronic HIV infection and its expression o...

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Detalles Bibliográficos
Autores principales: Juno, Jennifer A, Stalker, Andrew T, Waruk, Jillian LM, Oyugi, Julius, Kimani, Makobu, Plummer, Francis A, Kimani, Joshua, Fowke, Keith R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332911/
https://www.ncbi.nlm.nih.gov/pubmed/25810006
http://dx.doi.org/10.1186/s12977-015-0142-z

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