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Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial
Objective. To determine if sexual intercourse reduces absorption of vaginal progesterone gel in women and to determine if progesterone is absorbed by the male during intercourse. Study Design. Prospective, randomized, cross over, controlled study of 20 reproductive-aged women and their male sexual p...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332976/ https://www.ncbi.nlm.nih.gov/pubmed/25713585 http://dx.doi.org/10.1155/2015/685281 |
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author | Merriam, Kathryn S. Leake, Kristina A. Elliot, Mollie Matthews, Michelle L. Usadi, Rebecca S. Hurst, Bradley S. |
author_facet | Merriam, Kathryn S. Leake, Kristina A. Elliot, Mollie Matthews, Michelle L. Usadi, Rebecca S. Hurst, Bradley S. |
author_sort | Merriam, Kathryn S. |
collection | PubMed |
description | Objective. To determine if sexual intercourse reduces absorption of vaginal progesterone gel in women and to determine if progesterone is absorbed by the male during intercourse. Study Design. Prospective, randomized, cross over, controlled study of 20 reproductive-aged women and their male sexual partners randomized to receive vaginal progesterone gel (Crinone 8% gel, Actavis Inc., USA) or placebo cream. Serum progesterone for both male and female partners were measured 10 hours after intercourse. One week later, subjects were crossed over to receive the opposite formulation. In the third week, women used progesterone gel at night and abstained from intercourse. Results. Serum progesterone was significantly reduced with vaginal progesterone gel + intercourse compared with vaginal progesterone gel + abstinence (P = 0.0075). Men absorbed significant progesterone during intercourse with a female partner using vaginal progesterone gel compared to placebo (P = 0.0008). Conclusion(s). Vaginal progesterone gel is reduced in women after intercourse which may decrease drug efficacy during luteal phase support. Because men absorb low levels of progesterone during intercourse, exposure could cause adverse effects such as decreased libido. This study is registered under Clinical Trial number NCT01959464. |
format | Online Article Text |
id | pubmed-4332976 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43329762015-02-24 Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial Merriam, Kathryn S. Leake, Kristina A. Elliot, Mollie Matthews, Michelle L. Usadi, Rebecca S. Hurst, Bradley S. Int J Endocrinol Clinical Study Objective. To determine if sexual intercourse reduces absorption of vaginal progesterone gel in women and to determine if progesterone is absorbed by the male during intercourse. Study Design. Prospective, randomized, cross over, controlled study of 20 reproductive-aged women and their male sexual partners randomized to receive vaginal progesterone gel (Crinone 8% gel, Actavis Inc., USA) or placebo cream. Serum progesterone for both male and female partners were measured 10 hours after intercourse. One week later, subjects were crossed over to receive the opposite formulation. In the third week, women used progesterone gel at night and abstained from intercourse. Results. Serum progesterone was significantly reduced with vaginal progesterone gel + intercourse compared with vaginal progesterone gel + abstinence (P = 0.0075). Men absorbed significant progesterone during intercourse with a female partner using vaginal progesterone gel compared to placebo (P = 0.0008). Conclusion(s). Vaginal progesterone gel is reduced in women after intercourse which may decrease drug efficacy during luteal phase support. Because men absorb low levels of progesterone during intercourse, exposure could cause adverse effects such as decreased libido. This study is registered under Clinical Trial number NCT01959464. Hindawi Publishing Corporation 2015 2015-02-03 /pmc/articles/PMC4332976/ /pubmed/25713585 http://dx.doi.org/10.1155/2015/685281 Text en Copyright © 2015 Kathryn S. Merriam et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Merriam, Kathryn S. Leake, Kristina A. Elliot, Mollie Matthews, Michelle L. Usadi, Rebecca S. Hurst, Bradley S. Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial |
title | Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial |
title_full | Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial |
title_fullStr | Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial |
title_full_unstemmed | Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial |
title_short | Sexual Absorption of Vaginal Progesterone: A Randomized Control Trial |
title_sort | sexual absorption of vaginal progesterone: a randomized control trial |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332976/ https://www.ncbi.nlm.nih.gov/pubmed/25713585 http://dx.doi.org/10.1155/2015/685281 |
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