New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases

The processes that control the number and shape of the mitochondria (mitochondrial dynamics) and the removal of damaged mitochondria (mitophagy) have been the subject of intense research. Recent work indicates that these processes may contribute to the pathology associated with cardiac diseases. Thi...

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Autores principales: Disatnik, Marie-Hélène, Hwang, Sunhee, Ferreira, Julio C. B., Mochly-Rosen, Daria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333238/
https://www.ncbi.nlm.nih.gov/pubmed/25652199
http://dx.doi.org/10.1007/s00109-015-1256-4
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author Disatnik, Marie-Hélène
Hwang, Sunhee
Ferreira, Julio C. B.
Mochly-Rosen, Daria
author_facet Disatnik, Marie-Hélène
Hwang, Sunhee
Ferreira, Julio C. B.
Mochly-Rosen, Daria
author_sort Disatnik, Marie-Hélène
collection PubMed
description The processes that control the number and shape of the mitochondria (mitochondrial dynamics) and the removal of damaged mitochondria (mitophagy) have been the subject of intense research. Recent work indicates that these processes may contribute to the pathology associated with cardiac diseases. This review describes some of the key proteins that regulate these processes and their potential as therapeutic targets for cardiac diseases.
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spelling pubmed-43332382015-02-24 New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases Disatnik, Marie-Hélène Hwang, Sunhee Ferreira, Julio C. B. Mochly-Rosen, Daria J Mol Med (Berl) Review The processes that control the number and shape of the mitochondria (mitochondrial dynamics) and the removal of damaged mitochondria (mitophagy) have been the subject of intense research. Recent work indicates that these processes may contribute to the pathology associated with cardiac diseases. This review describes some of the key proteins that regulate these processes and their potential as therapeutic targets for cardiac diseases. Springer Berlin Heidelberg 2015-02-05 2015 /pmc/articles/PMC4333238/ /pubmed/25652199 http://dx.doi.org/10.1007/s00109-015-1256-4 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review
Disatnik, Marie-Hélène
Hwang, Sunhee
Ferreira, Julio C. B.
Mochly-Rosen, Daria
New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases
title New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases
title_full New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases
title_fullStr New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases
title_full_unstemmed New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases
title_short New therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases
title_sort new therapeutics to modulate mitochondrial dynamics and mitophagy in cardiac diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333238/
https://www.ncbi.nlm.nih.gov/pubmed/25652199
http://dx.doi.org/10.1007/s00109-015-1256-4
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